PMID- 16628010
OWN - NLM
STAT- MEDLINE
DCOM- 20060605
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 5
IP  - 9
DP  - 2006 May
TI  - ATF3 regulates the stability of p53: a link to cancer.
PG  - 926-9
AB  - ATF3 is a member of the ATF/CREB family of transcription factors involved in the 
      cellular response to a large variety of stresses including DNA damage. However, 
      neither the signaling leading to nor the biological significance of its induction 
      upon stress is well understood. Although it is generally believed that ATF3 
      exerts its function in the stress response by regulating transcription, to date, 
      only a limited number of target genes have been identified. We recently reported 
      that ATF3 interacts with the tumor suppressor p53 to increase its stability in 
      the genotoxic response. While providing the cell a general means of responding to 
      diverse adverse environment cues, this mechanism confers ATF3 with an ability to 
      promote tumor suppressor functions. Conversely, dysfunction of ATF3 impairs the 
      p53-mediated cellular response to DNA damage, allowing cells to be readily 
      transformed by oncogenes. Consistent with this notion is the observation of 
      downregulated ATF3 expression in most human cancers. Therefore, our findings 
      indicate that ATF3 intersects with p53-associated pathways ensuring genomic 
      integrity. The ability of ATF3 to stabilize p53-induced pathways thus represents 
      a means of effectively countering DNA damage caused by environmental insult the 
      latter leading to oncogene activation and ultimately malignant transformation.
FAU - Yan, Chunhong
AU  - Yan C
AD  - Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas 77030, USA.
FAU - Boyd, Douglas D
AU  - Boyd DD
LA  - eng
PT  - Journal Article
DEP - 20060501
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (ATF3 protein, human)
RN  - 0 (Activating Transcription Factor 3)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Activating Transcription Factor 3/genetics/*physiology
MH  - DNA Damage/physiology
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Models, Biological
MH  - Neoplasms/*genetics
MH  - Transcriptional Activation
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
EDAT- 2006/04/22 09:00
MHDA- 2006/06/06 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2006/06/06 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
AID - 2714 [pii]
AID - 10.4161/cc.5.9.2714 [doi]
PST - ppublish
SO  - Cell Cycle. 2006 May;5(9):926-9. doi: 10.4161/cc.5.9.2714. Epub 2006 May 1.