PMID- 1669702
OWN - NLM
STAT- MEDLINE
DCOM- 19940301
LR  - 20191028
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 1
IP  - 2
DP  - 1991 Jan
TI  - Migration of hematogenous cells through the blood-brain barrier and the 
      initiation of CNS inflammation.
PG  - 97-105
AB  - The central nervous system has long been considered an immunologically privileged 
      site. Nevertheless, cells derived from the bone marrow can and do enter the CNS 
      in a number of circumstances. Derivatives of the monocyte/macrophage lineage 
      appear to enter and take up residence in various structures of the CNS as part of 
      normal ontogeny and physiology. Immunocompetent cells, such as T-lymphocytes of 
      both CD4 and CD8 positive groups, enter the nervous system in what appears to be 
      a random fashion when they are activated by antigenic stimulation. These 
      lymphocytes perform the required immunological surveillance of the CNS, and 
      initiate inflammation therein during infectious and autoimmune reactions. In this 
      review, the evidence supporting the above observations is examined, and a 
      hypothesis for the pathogenesis of CNS inflammatory reactions is presented.
FAU - Hickey, W F
AU  - Hickey WF
AD  - Department of Pathology, Washington University Medical School, Saint Louis, 
      Missouri 63110.
LA  - eng
GR  - NS 27321/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
SB  - IM
GS  - V&bgr;8.2
MH  - Animals
MH  - Antigen-Presenting Cells/immunology/physiology
MH  - *Blood-Brain Barrier/physiology
MH  - Cell Movement
MH  - Central Nervous System Diseases/immunology/*physiopathology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/physiopathology
MH  - Humans
MH  - Inflammation
MH  - Leukocytes/immunology/*physiology
MH  - Models, Biological
MH  - Monocytes/immunology/physiology
MH  - Multiple Sclerosis/immunology/physiopathology
MH  - Rats
MH  - T-Lymphocyte Subsets/immunology/physiology
RF  - 109
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1111/j.1750-3639.1991.tb00646.x [doi]
PST - ppublish
SO  - Brain Pathol. 1991 Jan;1(2):97-105. doi: 10.1111/j.1750-3639.1991.tb00646.x.