PMID- 16732273
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20220331
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 9
IP  - 7
DP  - 2006 Jul
TI  - Control of microglial neurotoxicity by the fractalkine receptor.
PG  - 917-24
AB  - Microglia, the resident inflammatory cells of the CNS, are the only CNS cells 
      that express the fractalkine receptor (CX3CR1). Using three different in vivo 
      models, we show that CX3CR1 deficiency dysregulates microglial responses, 
      resulting in neurotoxicity. Following peripheral lipopolysaccharide injections, 
      Cx3cr1-/- mice showed cell-autonomous microglial neurotoxicity. In a toxic model 
      of Parkinson disease and a transgenic model of amyotrophic lateral sclerosis, 
      Cx3cr1-/- mice showed more extensive neuronal cell loss than Cx3cr1+ littermate 
      controls. Augmenting CX3CR1 signaling may protect against microglial 
      neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could 
      increase neuronal vulnerability.
FAU - Cardona, Astrid E
AU  - Cardona AE
AD  - Neuroinflammation Research Center and Department of Neurosciences, Lerner 
      Research Institute, Cleveland, Ohio 44195, USA.
FAU - Pioro, Erik P
AU  - Pioro EP
FAU - Sasse, Margaret E
AU  - Sasse ME
FAU - Kostenko, Volodymyr
AU  - Kostenko V
FAU - Cardona, Sandra M
AU  - Cardona SM
FAU - Dijkstra, Ineke M
AU  - Dijkstra IM
FAU - Huang, Deren
AU  - Huang D
FAU - Kidd, Grahame
AU  - Kidd G
FAU - Dombrowski, Stephen
AU  - Dombrowski S
FAU - Dutta, RanJan
AU  - Dutta R
FAU - Lee, Jar-Chi
AU  - Lee JC
FAU - Cook, Donald N
AU  - Cook DN
FAU - Jung, Steffen
AU  - Jung S
FAU - Lira, Sergio A
AU  - Lira SA
FAU - Littman, Dan R
AU  - Littman DR
FAU - Ransohoff, Richard M
AU  - Ransohoff RM
LA  - eng
GR  - NS32151/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060618
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Aif1 protein, mouse)
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Chemokine)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
CIN - Nat Neurosci. 2006 Jul;9(7):859-61. PMID: 16801915
MH  - Analysis of Variance
MH  - Animals
MH  - CX3C Chemokine Receptor 1
MH  - Calcium-Binding Proteins/metabolism
MH  - Cell Death/drug effects
MH  - Cells, Cultured
MH  - Central Nervous System/cytology
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Flow Cytometry
MH  - Green Fluorescent Proteins/metabolism
MH  - Immunohistochemistry/methods
MH  - Lipopolysaccharides/administration & dosage
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microfilament Proteins
MH  - Microglia/*drug effects/*physiology
MH  - Motor Neuron Disease/genetics/metabolism/pathology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/drug effects
MH  - Neurotoxicity Syndromes/etiology/genetics/*metabolism/*pathology
MH  - Parkinson Disease/genetics/metabolism/pathology
MH  - Receptors, Chemokine/deficiency/*physiology
EDAT- 2006/05/30 09:00
MHDA- 2006/09/06 09:00
CRDT- 2006/05/30 09:00
PHST- 2006/03/06 00:00 [received]
PHST- 2006/05/05 00:00 [accepted]
PHST- 2006/05/30 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/05/30 09:00 [entrez]
AID - nn1715 [pii]
AID - 10.1038/nn1715 [doi]
PST - ppublish
SO  - Nat Neurosci. 2006 Jul;9(7):917-24. doi: 10.1038/nn1715. Epub 2006 Jun 18.