PMID- 16771693
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20240408
IS  - 1523-0864 (Print)
IS  - 1523-0864 (Linking)
VI  - 8
IP  - 5-6
DP  - 2006 May-Jun
TI  - 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen 
      species: formation, occurrence, and implications in inflammation and 
      carcinogenesis.
PG  - 1033-45
AB  - The authors review studies on 8-nitroguanine (8-NO(2)-G) formed by reactions of 
      guanine, guanosine, and 2 - deoxyguanosine, either free or in DNA or RNAwith 
      reactive nitrogen species (RNS) generated from peroxynitrite, the 
      myeloperoxidase-H(2)O(2)-nitrite system, and others. Use of antibodies against 
      8-NO(2)-G has revealed increased formation of 8-NO(2)-G in various pathological 
      conditions, including RNA virus-induced pneumonia in mice, intrahepatic bile 
      ducts of hamsters infected with the liver fluke Opisthorchis viverrini, and 
      gastric mucosa of patients with Helicobacter pylori-induced gastritis. 
      Immunoreactivity has been found in the cytosol as well as in the nucleus of 
      inflammatory cells and epithelial cells in inflamed tissues, but not in normal 
      tissues. 8- NO(2)-G in DNA is potentially mutagenic, yielding G:C to T:A 
      transversion, possibly through its rapid depurination to form an apurinic site 
      and/or miscoding with adenine. 8-NO(2)-G in RNA may interfere with RNA functions 
      and metabolism. Nitrated guanine nucleosides and nucleotides in the nucleotide 
      pool may contribute to oxidative stress via production of superoxide mediated by 
      various reductases and may disturb or modulate directly various important enzymes 
      such as GTP-binding proteins and cGMP-dependent enzymes. Further studies are 
      warranted to establish the roles of 8-NO(2)-G in various pathophysiological 
      conditions and inflammation-associated cancer.
FAU - Ohshima, Hiroshi
AU  - Ohshima H
AD  - International Agency for Research on Cancer, Lyon, France. 
      ohshimah@u-shizouoka-ken.ac.jp
FAU - Sawa, Tomohiro
AU  - Sawa T
FAU - Akaike, Takaaki
AU  - Akaike T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (8-nitroguanine)
RN  - 0 (Reactive Nitrogen Species)
RN  - 14691-52-2 (Peroxynitrous Acid)
RN  - 5Z93L87A1R (Guanine)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Antioxid Redox Signal. 2006 May-Jun;8(5-6):981-3. PMID: 16771687
MH  - Animals
MH  - DNA/chemistry/metabolism
MH  - *DNA Damage
MH  - Guanine/*analogs & derivatives/chemistry/metabolism
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Lung/cytology/metabolism
MH  - Molecular Structure
MH  - Neoplasms/*metabolism
MH  - Peroxynitrous Acid/chemistry/metabolism
MH  - RNA/chemistry/metabolism
MH  - Reactive Nitrogen Species/*metabolism
MH  - Signal Transduction/physiology
RF  - 83
EDAT- 2006/06/15 09:00
MHDA- 2007/03/28 09:00
CRDT- 2006/06/15 09:00
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - 10.1089/ars.2006.8.1033 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2006 May-Jun;8(5-6):1033-45. doi: 10.1089/ars.2006.8.1033.