PMID- 16829981
OWN - NLM
STAT- MEDLINE
DCOM- 20060829
LR  - 20250214
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 7
IP  - 7
DP  - 2006 Jul
TI  - EGF-ERBB signalling: towards the systems level.
PG  - 505-16
AB  - Signalling through the ERBB/HER receptors is intricately involved in human cancer 
      and already serves as a target for several cancer drugs. Because of its inherent 
      complexity, it is useful to envision ERBB signalling as a bow-tie-configured, 
      evolvable network, which shares modularity, redundancy and control circuits with 
      robust biological and engineered systems. Because network fragility is an 
      inevitable trade-off of robustness, systems-level understanding is expected to 
      generate therapeutic opportunities to intercept aberrant network activation.
FAU - Citri, Ami
AU  - Citri A
AD  - Department of Biological Regulation, the Weizmann Institute of Science, 1 Hertzl 
      Street, Rehovot 76100, Israel.
FAU - Yarden, Yosef
AU  - Yarden Y
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Ligands)
RN  - 0 (Oncogene Proteins v-erbB)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Animals
MH  - Endocytosis/physiology
MH  - Epidermal Growth Factor/*metabolism
MH  - ErbB Receptors/chemistry/genetics/metabolism
MH  - Feedback, Physiological
MH  - Humans
MH  - Ligands
MH  - Models, Molecular
MH  - Oncogene Proteins v-erbB/genetics/*metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Conformation
MH  - Signal Transduction/*physiology
RF  - 142
EDAT- 2006/07/11 09:00
MHDA- 2006/08/30 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/08/30 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - nrm1962 [pii]
AID - 10.1038/nrm1962 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16. doi: 10.1038/nrm1962.