PMID- 16885505
OWN - NLM
STAT- MEDLINE
DCOM- 20070928
LR  - 20060928
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 80
IP  - 4
DP  - 2006 Oct
TI  - T cells traffic from brain to cervical lymph nodes via the cribroid plate and the 
      nasal mucosa.
PG  - 797-801
AB  - Although drainage pathways of soluble antigens from brain to cervical lymph nodes 
      have been well established, there is no direct evidence for similar routes of 
      leukocytes leaving the central nervous system. We developed a protocol allowing 
      the cross-sectioning of an entire head-neck preparation while preserving the 
      signal of the GFP. We monitored how GFP-expressing CD4 T lymphocytes injected 
      into the entorhinal cortex after lesion or the lateral ventricle of unlesioned 
      C57/bl6 mice reach cervical lymph nodes. Irrespective of the injection site, we 
      demonstrate their passage through the cribroid plate, appearance in the nasal 
      mucosa, and specific accumulation in one of the cervical lymph nodes.
FAU - Goldmann, Jana
AU  - Goldmann J
AD  - Department of Experimental Neuroimmunology, Charite, Universitatsmedizin, Berlin, 
      Germany.
FAU - Kwidzinski, Erik
AU  - Kwidzinski E
FAU - Brandt, Christine
AU  - Brandt C
FAU - Mahlo, Jacqueline
AU  - Mahlo J
FAU - Richter, Daniel
AU  - Richter D
FAU - Bechmann, Ingo
AU  - Bechmann I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060802
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - Brain/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Movement/*immunology
MH  - Disease Models, Animal
MH  - Ethmoid Bone/*immunology
MH  - Green Fluorescent Proteins/administration & dosage/immunology
MH  - Lymph Nodes/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Nasal Mucosa/*immunology
MH  - Neck
EDAT- 2006/08/04 09:00
MHDA- 2007/09/29 09:00
CRDT- 2006/08/04 09:00
PHST- 2006/08/04 09:00 [pubmed]
PHST- 2007/09/29 09:00 [medline]
PHST- 2006/08/04 09:00 [entrez]
AID - jlb.0306176 [pii]
AID - 10.1189/jlb.0306176 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2006 Oct;80(4):797-801. doi: 10.1189/jlb.0306176. Epub 2006 Aug 2.