PMID- 17063185
OWN - NLM
STAT- MEDLINE
DCOM- 20061215
LR  - 20220318
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 6
IP  - 11
DP  - 2006 Nov
TI  - Interferons, immunity and cancer immunoediting.
PG  - 836-48
AB  - A clear picture of the dynamic relationship between the host immune system and 
      cancer is emerging as the cells and molecules that participate in naturally 
      occurring antitumour immune responses are being identified. The interferons 
      (IFNs) - that is, the type I IFNs (IFNalpha and IFNbeta) and type II IFN 
      (IFNgamma) - have emerged as central coordinators of tumour-immune-system 
      interactions. Indeed, the decade-old finding that IFNgamma has a pivotal role in 
      promoting antitumour responses became the focus for a renewed interest in the 
      largely abandoned concept of cancer immunosurveillance. More recently, type I 
      IFNs have been found to have distinct functions in this process. In this Review, 
      we discuss the roles of the IFNs, not only in cancer immunosurveillance but also 
      in the broader process of cancer immunoediting.
FAU - Dunn, Gavin P
AU  - Dunn GP
AD  - Washington University School of Medicine, Department of Pathology and Immunology, 
      Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
FAU - Koebel, Catherine M
AU  - Koebel CM
FAU - Schreiber, Robert D
AU  - Schreiber RD
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunity/*immunology
MH  - Immunotherapy
MH  - Interferons/biosynthesis/*immunology
MH  - Monitoring, Immunologic
MH  - Neoplasms/*immunology/metabolism/therapy
MH  - Signal Transduction
RF  - 113
EDAT- 2006/10/26 09:00
MHDA- 2006/12/16 09:00
CRDT- 2006/10/26 09:00
PHST- 2006/10/26 09:00 [pubmed]
PHST- 2006/12/16 09:00 [medline]
PHST- 2006/10/26 09:00 [entrez]
AID - nri1961 [pii]
AID - 10.1038/nri1961 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2006 Nov;6(11):836-48. doi: 10.1038/nri1961.