PMID- 17093496
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20240413
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 25
IP  - 23
DP  - 2006 Nov 29
TI  - The contact system--a novel branch of innate immunity generating antibacterial 
      peptides.
PG  - 5569-78
AB  - Activation of the contact system has two classical consequences: initiation of 
      the intrinsic pathway of coagulation, and cleavage of high molecular weight 
      kininogen (HK) leading to the release of bradykinin, a potent proinflammatory 
      peptide. In human plasma, activation of the contact system at the surface of 
      significant bacterial pathogens was found to result in further HK processing and 
      bacterial killing. A fragment comprising the D3 domain of HK is generated, and 
      within this fragment a sequence of 26 amino acids is mainly responsible for the 
      antibacterial activity. A synthetic peptide covering this sequence kills several 
      bacterial species, also at physiological salt concentration, as effectively as 
      the classical human antibacterial peptide LL-37. Moreover, in an animal model of 
      infection, inhibition of the contact system promotes bacterial dissemination and 
      growth. These data identify a novel and important role for the contact system in 
      the defence against invasive bacterial infection.
FAU - Frick, Inga-Maria
AU  - Frick IM
AD  - Department of Clinical Sciences, Lund University, Sweden, and Department of 
      Clinical Chemistry and Clinical Biochemistry, University Hospital of 
      Surgery-City, Ludwig-Maximilians-University, Munich, Germany. 
      Inga-Maria.Frick@med.lu.se
FAU - Akesson, Per
AU  - Akesson P
FAU - Herwald, Heiko
AU  - Herwald H
FAU - Morgelin, Matthias
AU  - Morgelin M
FAU - Malmsten, Martin
AU  - Malmsten M
FAU - Nagler, Dorit K
AU  - Nagler DK
FAU - Bjorck, Lars
AU  - Bjorck L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061109
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Kininogen, High-Molecular-Weight)
RN  - 0 (Peptides)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/*pharmacology
MH  - Bacteria/*drug effects
MH  - Humans
MH  - *Immunity, Innate
MH  - Kininogen, High-Molecular-Weight/chemistry/metabolism/*pharmacology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Peptides/chemistry/*pharmacology
MH  - Protein Structure, Tertiary
PMC - PMC1679765
EDAT- 2006/11/10 09:00
MHDA- 2007/01/27 09:00
PMCR- 2007/11/29
CRDT- 2006/11/10 09:00
PHST- 2006/06/28 00:00 [received]
PHST- 2006/10/12 00:00 [accepted]
PHST- 2006/11/10 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/11/10 09:00 [entrez]
PHST- 2007/11/29 00:00 [pmc-release]
AID - 7601422 [pii]
AID - 10.1038/sj.emboj.7601422 [doi]
PST - ppublish
SO  - EMBO J. 2006 Nov 29;25(23):5569-78. doi: 10.1038/sj.emboj.7601422. Epub 2006 Nov 
      9.