PMID- 17129764
OWN - NLM
STAT- MEDLINE
DCOM- 20070309
LR  - 20220311
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 28
IP  - 1
DP  - 2007 Jan
TI  - What is immune privilege (not)?
PG  - 12-8
AB  - The 'immune privilege' of the central nervous system (CNS) is indispensable for 
      damage limitation during inflammation in a sensitive organ with poor regenerative 
      capacity. It is a longstanding notion which, over time, has acquired several 
      misconceptions and a lack of precision in its definition. In this article, we 
      address these issues and re-define CNS immune privilege in the light of recent 
      data. We show how it is far from absolute, and how it varies with age and brain 
      region. Immune privilege in the CNS is often mis-attributed wholly to the 
      blood-brain barrier. We discuss the pivotal role of the specialization of the 
      afferent arm of adaptive immunity in the brain, which results in a lack of 
      cell-mediated antigen drainage to the cervical lymph nodes although soluble 
      drainage to these nodes is well described. It is now increasingly recognized how 
      immune privilege is maintained actively as a result of the immunoregulatory 
      characteristics of the CNS-resident cells and their microenvironment.
FAU - Galea, Ian
AU  - Galea I
AD  - CNS Inflammation Group, School of Biological Sciences, University of Southampton, 
      SO16 7PX, UK. I.Galea@soton.ac.uk
FAU - Bechmann, Ingo
AU  - Bechmann I
FAU - Perry, V Hugh
AU  - Perry VH
LA  - eng
GR  - 784/MSS_/Multiple Sclerosis Society/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061128
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*immunology
MH  - Brain/immunology
MH  - Central Nervous System/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Mice
MH  - Rats
EDAT- 2006/11/30 09:00
MHDA- 2007/03/10 09:00
CRDT- 2006/11/30 09:00
PHST- 2006/09/11 00:00 [received]
PHST- 2006/10/27 00:00 [revised]
PHST- 2006/11/15 00:00 [accepted]
PHST- 2006/11/30 09:00 [pubmed]
PHST- 2007/03/10 09:00 [medline]
PHST- 2006/11/30 09:00 [entrez]
AID - S1471-4906(06)00326-7 [pii]
AID - 10.1016/j.it.2006.11.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2007 Jan;28(1):12-8. doi: 10.1016/j.it.2006.11.004. Epub 2006 Nov 
      28.