PMID- 17140851
OWN - NLM
STAT- MEDLINE
DCOM- 20070309
LR  - 20220223
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 28
IP  - 1
DP  - 2007 Jan
TI  - What is the blood-brain barrier (not)?
PG  - 5-11
AB  - In 1900, summarizing his experiments with toxins and Ehrlich's earlier 
      observations with intravital dyes, the Berlin physician Lewandowski concluded 
      that "brain capillaries must hold back certain molecules". Illustrating this 
      phenomenon with persuasive beauty, the subsequently evolving metaphor of a 
      'Bluthirnschranke' (blood-brain barrier, BBB) gained wide acceptance, but the 
      extension of its meaning into the context of inhibiting leukocyte recruitment 
      into the brain is imprecise. On the basis of the original work by Ehrlich, 
      Lewandowski and Goldmann we re-define the BBB as a capillary barrier for solutes, 
      and clarify that leukocyte recruitment requires two differentially regulated 
      steps: (i) passage across postcapillary venules into Virchow-Robin spaces, and 
      (ii) subsequent progression across the glia limitans into the neuropil. We 
      propose that the second step frequently involves perivascular antigen-recognition 
      and the induction of ectoenzymes, for example matrix metalloproteinases (MMPs).
FAU - Bechmann, Ingo
AU  - Bechmann I
AD  - Dr. Senckenbergische Anatomie, Institute of Clinical Neuroanatomy, Johann 
      Wolfgang Goethe-University, 60 590 Frankfurt, Germany. 
      Bechmann@med.uni-frankfurt.de
FAU - Galea, Ian
AU  - Galea I
FAU - Perry, V Hugh
AU  - Perry VH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061130
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Blood-Brain Barrier/*immunology
MH  - Brain/*blood supply/*immunology
MH  - Humans
MH  - Models, Immunological
EDAT- 2006/12/05 09:00
MHDA- 2007/03/10 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/09/11 00:00 [received]
PHST- 2006/10/30 00:00 [revised]
PHST- 2006/11/16 00:00 [accepted]
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2007/03/10 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - S1471-4906(06)00329-2 [pii]
AID - 10.1016/j.it.2006.11.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2007 Jan;28(1):5-11. doi: 10.1016/j.it.2006.11.007. Epub 2006 Nov 
      30.