PMID- 17143233
OWN - NLM
STAT- MEDLINE
DCOM- 20061228
LR  - 20151119
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 59
IP  - 5
DP  - 2006 Nov
TI  - Dendritic cell vaccination in patients with malignant gliomas: current status and 
      future directions.
PG  - 988-99; discussioin 999-1000
AB  - OBJECTIVE: Despite recent advances in neurosurgical resection techniques, 
      radiation therapy, and chemotherapy, malignant gliomas continue to have a dismal 
      prognosis because relapses are unavoidable. METHODS: Dendritic cell vaccination 
      has recently emerged as a promising type of active immunotherapy that aims to 
      induce rather than transfer specific antitumor immune responses in patients. 
      Active immunotherapy is the only type of immunotherapy able to induce 
      immunological memory. RESULTS: Although an increasing number of small clinical 
      trials show safety, feasibility, and immunological and clinical responses, this 
      technology requires further clarification of some critical basic and clinical 
      issues before its presumed place in the treatment of malignant gliomas can be 
      specified. This article addresses the basic and clinical pitfalls that, more than 
      with conventional therapies, may interfere with the potential benefits of this 
      approach. CONCLUSION: Considering the particular mechanisms involved in the 
      immune modulation of tumor biology using dendritic cell-based vaccinations, the 
      authors summarize the arguments in favor of a further, appropriate assessment of 
      this technology.
FAU - de Vleeschouwer, Steven
AU  - de Vleeschouwer S
AD  - Department of Neurosurgery, University Hospital Gasthuisberg, Leuven, Belgium. 
      Steven.devleeschouwer@uz.kuleuven.ac.be
FAU - Rapp, Marion
AU  - Rapp M
FAU - Sorg, Rudiger V
AU  - Sorg RV
FAU - Steiger, Hans-Jakob
AU  - Steiger HJ
FAU - Stummer, Walter
AU  - Stummer W
FAU - van Gool, Stefaan
AU  - van Gool S
FAU - Sabel, Michael
AU  - Sabel M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Brain Neoplasms/immunology/*prevention & control
MH  - Dendritic Cells/immunology/*transplantation
MH  - Forecasting
MH  - Glioma/immunology/*prevention & control
MH  - Humans
MH  - Immunotherapy, Adoptive/*methods/*trends
MH  - Practice Patterns, Physicians'/*trends
MH  - Vaccination/methods/*trends
RF  - 112
EDAT- 2006/12/05 09:00
MHDA- 2006/12/29 09:00
CRDT- 2006/12/05 09:00
PHST- 2006/12/05 09:00 [pubmed]
PHST- 2006/12/29 09:00 [medline]
PHST- 2006/12/05 09:00 [entrez]
AID - 00006123-200611000-00003 [pii]
AID - 10.1227/01.NEU.0000245595.38957.3E [doi]
PST - ppublish
SO  - Neurosurgery. 2006 Nov;59(5):988-99; discussioin 999-1000. doi: 
      10.1227/01.NEU.0000245595.38957.3E.