PMID- 17159987
OWN - NLM
STAT- MEDLINE
DCOM- 20070226
LR  - 20220408
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 13
IP  - 1
DP  - 2007 Jan
TI  - Loss of tumor suppressor PTEN function increases B7-H1 expression and 
      immunoresistance in glioma.
PG  - 84-8
AB  - Cancer immunoresistance and immune escape may play important roles in tumor 
      progression and pose obstacles for immunotherapy. Expression of the 
      immunosuppressive protein B7 homolog 1 (B7-H1), also known as programmed death 
      ligand-1 (PD-L1), is increased in many pathological conditions, including cancer. 
      Here we show that expression of the gene encoding B7-H1 increases post 
      transcriptionally in human glioma after loss of phosphatase and tensin homolog 
      (PTEN) and activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. 
      Tumor specimens from individuals with glioblastoma multiforme (GBM) had levels of 
      B7-H1 protein that correlated with PTEN loss, and tumor-specific T cells lysed 
      human glioma targets expressing wild-type PTEN more effectively than those 
      expressing mutant PTEN. These data identify a previously unrecognized mechanism 
      linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part 
      by B7-H1.
FAU - Parsa, Andrew T
AU  - Parsa AT
AD  - Department of Neurological Surgery, University of California San Francisco, 505 
      Parnassus Avenue, M-779, San Francisco, California 94143, USA. 
      parsaa@neurosurg.ucsf.edu
FAU - Waldron, James S
AU  - Waldron JS
FAU - Panner, Amith
AU  - Panner A
FAU - Crane, Courtney A
AU  - Crane CA
FAU - Parney, Ian F
AU  - Parney IF
FAU - Barry, Jeffrey J
AU  - Barry JJ
FAU - Cachola, Kristine E
AU  - Cachola KE
FAU - Murray, Joseph C
AU  - Murray JC
FAU - Tihan, Tarik
AU  - Tihan T
FAU - Jensen, Michael C
AU  - Jensen MC
FAU - Mischel, Paul S
AU  - Mischel PS
FAU - Stokoe, David
AU  - Stokoe D
FAU - Pieper, Russell O
AU  - Pieper RO
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061210
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (B7-H1 Antigen)
RN  - 0 (CD274 protein, human)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
RN  - EC 3.4.22.- (Caspase 6)
SB  - IM
MH  - Analysis of Variance
MH  - Antibodies, Monoclonal/pharmacology
MH  - Antigens, CD/*genetics/immunology/metabolism
MH  - B7-H1 Antigen
MH  - Blotting, Western
MH  - Caspase 6/metabolism
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Enzyme Activation/drug effects
MH  - Flow Cytometry
MH  - Glioblastoma/genetics/metabolism/pathology
MH  - Glioma/genetics/metabolism/*pathology
MH  - Humans
MH  - Mutation
MH  - PTEN Phosphohydrolase/*genetics/metabolism
MH  - Protein Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/antagonists & inhibitors/metabolism
MH  - RNA Interference
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ribosomal Protein S6 Kinases/genetics/metabolism
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases
MH  - Transfection
EDAT- 2006/12/13 09:00
MHDA- 2007/02/27 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/03/28 00:00 [received]
PHST- 2006/11/06 00:00 [accepted]
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/02/27 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - nm1517 [pii]
AID - 10.1038/nm1517 [doi]
PST - ppublish
SO  - Nat Med. 2007 Jan;13(1):84-8. doi: 10.1038/nm1517. Epub 2006 Dec 10.