PMID- 17186030
OWN - NLM
STAT- MEDLINE
DCOM- 20070213
LR  - 20220410
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 7
IP  - 1
DP  - 2007 Jan
TI  - Crosstalk between cancer and immune cells: role of STAT3 in the tumour 
      microenvironment.
PG  - 41-51
AB  - Immune cells in the tumour microenvironment not only fail to mount an effective 
      anti-tumour immune response, but also interact intimately with the transformed 
      cells to promote oncogenesis actively. Signal transducer and activator of 
      transcription 3 (STAT3), which is a point of convergence for numerous oncogenic 
      signalling pathways, is constitutively activated both in tumour cells and in 
      immune cells in the tumour microenvironment. Constitutively activated STAT3 
      inhibits the expression of mediators necessary for immune activation against 
      tumour cells. Furthermore, STAT3 activity promotes the production of 
      immunosuppressive factors that activate STAT3 in diverse immune-cell subsets, 
      altering gene-expression programmes and, thereby, restraining anti-tumour immune 
      responses. As such, STAT3 propagates several levels of crosstalk between tumour 
      cells and their immunological microenvironment, leading to tumour-induced 
      immunosuppression. Consequently, STAT3 has emerged as a promising target for 
      cancer immunotherapy.
FAU - Yu, Hua
AU  - Yu H
AD  - Division of Cancer Immunotherapeutics and Tumour Immunology, Beckman Research 
      Institute at the City of Hope National Medical Center, Duarte, California 91010, 
      USA. hyu@coh.org
FAU - Kortylewski, Marcin
AU  - Kortylewski M
FAU - Pardoll, Drew
AU  - Pardoll D
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (STAT3 Transcription Factor)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Leukocytes/*immunology/metabolism
MH  - Neoplasms/*immunology/metabolism
MH  - Receptor Cross-Talk
MH  - STAT3 Transcription Factor/*immunology
MH  - Signal Transduction/*immunology
MH  - Tumor Escape
RF  - 121
EDAT- 2006/12/23 09:00
MHDA- 2007/02/14 09:00
CRDT- 2006/12/23 09:00
PHST- 2006/12/23 09:00 [pubmed]
PHST- 2007/02/14 09:00 [medline]
PHST- 2006/12/23 09:00 [entrez]
AID - nri1995 [pii]
AID - 10.1038/nri1995 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2007 Jan;7(1):41-51. doi: 10.1038/nri1995.