PMID- 17222791
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20220825
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 11
IP  - 1
DP  - 2007 Jan
TI  - A perivascular niche for brain tumor stem cells.
PG  - 69-82
AB  - Cancers are believed to arise from cancer stem cells (CSCs), but it is not known 
      if these cells remain dependent upon the niche microenvironments that regulate 
      normal stem cells. We show that endothelial cells interact closely with 
      self-renewing brain tumor cells and secrete factors that maintain these cells in 
      a stem cell-like state. Increasing the number of endothelial cells or blood 
      vessels in orthotopic brain tumor xenografts expanded the fraction of 
      self-renewing cells and accelerated the initiation and growth of tumors. 
      Conversely, depletion of blood vessels from xenografts ablated self-renewing 
      cells from tumors and arrested tumor growth. We propose that brain CSCs are 
      maintained within vascular niches that are important targets for therapeutic 
      approaches.
FAU - Calabrese, Christopher
AU  - Calabrese C
AD  - Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 
      332 North Lauderdale Street, Memphis, TN 38105, USA.
FAU - Poppleton, Helen
AU  - Poppleton H
FAU - Kocak, Mehmet
AU  - Kocak M
FAU - Hogg, Twala L
AU  - Hogg TL
FAU - Fuller, Christine
AU  - Fuller C
FAU - Hamner, Blair
AU  - Hamner B
FAU - Oh, Eun Young
AU  - Oh EY
FAU - Gaber, M Waleed
AU  - Gaber MW
FAU - Finklestein, David
AU  - Finklestein D
FAU - Allen, Meredith
AU  - Allen M
FAU - Frank, Adrian
AU  - Frank A
FAU - Bayazitov, Ildar T
AU  - Bayazitov IT
FAU - Zakharenko, Stanislav S
AU  - Zakharenko SS
FAU - Gajjar, Amar
AU  - Gajjar A
FAU - Davidoff, Andrew
AU  - Davidoff A
FAU - Gilbertson, Richard J
AU  - Gilbertson RJ
LA  - eng
GR  - R01 MH079079/MH/NIMH NIH HHS/United States
GR  - R25 CA023944/CA/NCI NIH HHS/United States
GR  - CA096832/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Glycoproteins)
RN  - 0 (Peptides)
SB  - IM
CIN - Cancer Cell. 2007 Jan;11(1):3-5. PMID: 17222787
MH  - AC133 Antigen
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Brain Neoplasms/*blood supply/metabolism
MH  - Cell Communication/physiology
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - *Endothelial Cells/metabolism
MH  - Female
MH  - Gene Expression
MH  - Glycoproteins/metabolism
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Mice, Nude
MH  - *Neoplastic Stem Cells/metabolism
MH  - Neurons/metabolism/pathology
MH  - Peptides/metabolism
EDAT- 2007/01/16 09:00
MHDA- 2007/02/23 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/06/22 00:00 [received]
PHST- 2006/10/03 00:00 [revised]
PHST- 2006/11/28 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S1535-6108(06)00369-2 [pii]
AID - 10.1016/j.ccr.2006.11.020 [doi]
PST - ppublish
SO  - Cancer Cell. 2007 Jan;11(1):69-82. doi: 10.1016/j.ccr.2006.11.020.