PMID- 17296553
OWN - NLM
STAT- MEDLINE
DCOM- 20080428
LR  - 20220309
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 53
IP  - 4
DP  - 2007 Feb 15
TI  - Olig2-regulated lineage-restricted pathway controls replication competence in 
      neural stem cells and malignant glioma.
PG  - 503-17
AB  - Recent studies have identified stem cells in brain cancer. However, their 
      relationship to normal CNS progenitors, including dependence on common 
      lineage-restricted pathways, is unclear. We observe expression of the 
      CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor 
      cells reminiscent of type C transit-amplifying cells in germinal zones of the 
      adult brain. Olig2 function is required for proliferation of neural progenitors 
      and for glioma formation in a genetically relevant murine model. Moreover, we 
      show p21(WAF1/CIP1), a tumor suppressor and inhibitor of stem cell proliferation, 
      is directly repressed by OLIG2 in neural progenitors and gliomas. Our findings 
      identify an Olig2-regulated lineage-restricted pathway critical for proliferation 
      of normal and tumorigenic CNS stem cells.
FAU - Ligon, Keith L
AU  - Ligon KL
AD  - Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard 
      Medical School, 44 Binney Street, Boston, MA 02115, USA.
FAU - Huillard, Emmanuelle
AU  - Huillard E
FAU - Mehta, Shwetal
AU  - Mehta S
FAU - Kesari, Santosh
AU  - Kesari S
FAU - Liu, Hongye
AU  - Liu H
FAU - Alberta, John A
AU  - Alberta JA
FAU - Bachoo, Robert M
AU  - Bachoo RM
FAU - Kane, Michael
AU  - Kane M
FAU - Louis, David N
AU  - Louis DN
FAU - Depinho, Ronald A
AU  - Depinho RA
FAU - Anderson, David J
AU  - Anderson DJ
FAU - Stiles, Charles D
AU  - Stiles CD
FAU - Rowitch, David H
AU  - Rowitch DH
LA  - eng
GR  - R01 NS040511/NS/NINDS NIH HHS/United States
GR  - K08NS047213/NS/NINDS NIH HHS/United States
GR  - NS05563/NS/NINDS NIH HHS/United States
GR  - P01 CA095616/CA/NCI NIH HHS/United States
GR  - F32 NS055631/NS/NINDS NIH HHS/United States
GR  - P01 CA95616/CA/NCI NIH HHS/United States
GR  - P01 NS047572/NS/NINDS NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
GR  - P01NS047572/NS/NINDS NIH HHS/United States
GR  - R01NS40511/NS/NINDS NIH HHS/United States
GR  - K08 NS047213/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Olig2 protein, mouse)
RN  - 0 (Oligodendrocyte Transcription Factor 2)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 1.13.12.- (Luciferases)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors/deficiency/*metabolism
MH  - Brain Neoplasms/*pathology
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Chromatin Immunoprecipitation/methods
MH  - Cyclin-Dependent Kinase Inhibitor p16/deficiency
MH  - Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
MH  - Embryo, Mammalian
MH  - Flow Cytometry
MH  - Glioma/*pathology
MH  - Green Fluorescent Proteins/biosynthesis
MH  - Luciferases/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, SCID
MH  - Mice, Transgenic
MH  - Nerve Tissue Proteins/deficiency/*metabolism
MH  - Neurons/*physiology
MH  - Oligodendrocyte Transcription Factor 2
MH  - Stem Cells/*physiology
PMC - PMC1810344
MID - NIHMS18231
EDAT- 2007/02/14 09:00
MHDA- 2008/04/29 09:00
PMCR- 2008/02/15
CRDT- 2007/02/14 09:00
PHST- 2006/09/25 00:00 [received]
PHST- 2006/12/11 00:00 [revised]
PHST- 2007/01/10 00:00 [accepted]
PHST- 2007/02/14 09:00 [pubmed]
PHST- 2008/04/29 09:00 [medline]
PHST- 2007/02/14 09:00 [entrez]
PHST- 2008/02/15 00:00 [pmc-release]
AID - S0896-6273(07)00029-3 [pii]
AID - 10.1016/j.neuron.2007.01.009 [doi]
PST - ppublish
SO  - Neuron. 2007 Feb 15;53(4):503-17. doi: 10.1016/j.neuron.2007.01.009.