PMID- 17448990 OWN - NLM STAT- MEDLINE DCOM- 20070604 LR - 20220321 IS - 0092-8674 (Print) IS - 0092-8674 (Linking) VI - 129 IP - 2 DP - 2007 Apr 20 TI - Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. PG - 277-88 AB - To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilii. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous system development in annelids to that of other bilaterians could provide valuable information about the common ancestor of all Bilateria. We find that the Platynereis neuroectoderm is subdivided into longitudinal progenitor domains by partially overlapping expression regions of nk and pax genes. These domains match corresponding domains in the vertebrate neural tube and give rise to conserved neural cell types. As in vertebrates, neural patterning genes are sensitive to Bmp signaling. Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria. FAU - Denes, Alexandru S AU - Denes AS AD - Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, 69117, Germany. FAU - Jekely, Gaspar AU - Jekely G FAU - Steinmetz, Patrick R H AU - Steinmetz PR FAU - Raible, Florian AU - Raible F FAU - Snyman, Heidi AU - Snyman H FAU - Prud'homme, Benjamin AU - Prud'homme B FAU - Ferrier, David E K AU - Ferrier DE FAU - Balavoine, Guillaume AU - Balavoine G FAU - Arendt, Detlev AU - Arendt D LA - eng GR - BBS/B/12067/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Cell JT - Cell JID - 0413066 RN - 0 (Bone Morphogenetic Proteins) RN - 0 (Homeodomain Proteins) RN - 0 (Paired Box Transcription Factors) RN - 0 (Transcription Factors) SB - IM CIN - Cell. 2007 Apr 20;129(2):237-9. PMID: 17448982 MH - Animals MH - *Biological Evolution MH - *Body Patterning MH - Bone Morphogenetic Proteins/metabolism MH - Central Nervous System/*embryology MH - Gene Expression Regulation, Developmental MH - Homeodomain Proteins/genetics MH - Neurons/cytology/metabolism MH - Paired Box Transcription Factors/genetics MH - Polychaeta/*embryology MH - Transcription Factors/genetics MH - Vertebrates/embryology EDAT- 2007/04/24 09:00 MHDA- 2007/06/05 09:00 CRDT- 2007/04/24 09:00 PHST- 2006/08/04 00:00 [received] PHST- 2006/12/22 00:00 [revised] PHST- 2007/02/13 00:00 [accepted] PHST- 2007/04/24 09:00 [pubmed] PHST- 2007/06/05 09:00 [medline] PHST- 2007/04/24 09:00 [entrez] AID - S0092-8674(07)00326-1 [pii] AID - 10.1016/j.cell.2007.02.040 [doi] PST - ppublish SO - Cell. 2007 Apr 20;129(2):277-88. doi: 10.1016/j.cell.2007.02.040.