PMID- 17671896
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20191110
IS  - 1061-186X (Print)
IS  - 1026-7158 (Linking)
VI  - 15
IP  - 7-8
DP  - 2007 Aug-Sep
TI  - Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on 
      EPR effect and singlet oxygen generation.
PG  - 496-506
AB  - Polymeric micelles of zinc protoporphyrin (ZnPP) with water soluble biocompatible 
      and amphiphilic polymer, polyethylene glycol (PEG) demonstrated unique 
      characteristics to target tumor tissues selectively based on the enhanced 
      permeability and retention (EPR) effect. The micellar macromolecular drug of ZnPP 
      (SMA-ZnPP and PEG-ZnPP) previously showed notable anticancer activity as a 
      consequence of selective tumor targeting ability and its potent HO-1 inhibitory 
      potential, resulting in suppressed biliverdin/bilirubin production in tumors 
      thereby leading to oxystress induced tumor cell killing. Furthermore, recent 
      findings also showed that ZnPP efficiently generated reactive singlet oxygen 
      under illumination of visible light, laser, or xenon light source, which could 
      augment its oxystress induced cell killing abilities. In the present paper, we 
      report the synergistic effects of light induced photosensitizing capabilities and 
      HO-1 inhibitory potentials of these unique micelles when tested in vitro and in 
      vivo on tumor models under localized, mild illumination conditions using a 
      tungsten-xenon light source. The results indicate that these water soluble 
      polymeric micelles of ZnPP portend to be promising candidates for targeted 
      chemotherapy as well as photodynamic therapy against superficial tumors as well 
      as solid tumors located at light penetrable depths.
FAU - Iyer, Arun K
AU  - Iyer AK
AD  - Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo 
      University, Kumamoto, Japan.
FAU - Greish, Khaled
AU  - Greish K
FAU - Seki, Takahiro
AU  - Seki T
FAU - Okazaki, Shoko
AU  - Okazaki S
FAU - Fang, Jun
AU  - Fang J
FAU - Takeshita, Keizo
AU  - Takeshita K
FAU - Maeda, Hiroshi
AU  - Maeda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 0 (Protoporphyrins)
RN  - 15442-64-5 (zinc protoporphyrin)
RN  - 17778-80-2 (Singlet Oxygen)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - *Drug Delivery Systems
MH  - Enzyme Inhibitors/chemistry/pharmacokinetics/*pharmacology
MH  - Female
MH  - Heme Oxygenase-1/metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Micelles
MH  - Neoplasms/*drug therapy
MH  - Permeability
MH  - *Photochemotherapy
MH  - Polyethylene Glycols/chemistry
MH  - Polymers/chemical synthesis/chemistry
MH  - Protoporphyrins/chemistry/pharmacokinetics/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Singlet Oxygen
EDAT- 2007/08/03 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/08/03 09:00
PHST- 2007/08/03 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/08/03 09:00 [entrez]
AID - 779858690 [pii]
AID - 10.1080/10611860701498252 [doi]
PST - ppublish
SO  - J Drug Target. 2007 Aug-Sep;15(7-8):496-506. doi: 10.1080/10611860701498252.