PMID- 17681175
OWN - NLM
STAT- MEDLINE
DCOM- 20070906
LR  - 20081121
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 133
IP  - 2
DP  - 2007 Aug
TI  - SOX9 is required for the differentiation of paneth cells in the intestinal 
      epithelium.
PG  - 539-46
AB  - BACKGROUND AND AIMS: The transcription factor SOX9 has been shown previously to 
      have an essential role in the differentiation of a small number of discrete cell 
      lineages. In the intestine, Sox9 is expressed in the epithelial cells of the 
      crypts and is a target of Wnt signaling. METHODS: To examine the function of SOX9 
      in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by 
      generating mice that harbored a conditional Sox9 gene and a Villin-Cre transgene. 
      RESULTS: In the absence of SOX9, Paneth cells were not formed, but the 
      differentiation of other intestinal epithelial cell types was unaffected. The 
      lack of SOX9 also lead to crypt enlargement, to a marked increase in cell 
      proliferation throughout the crypts, and to replacement of the Paneth cells by 
      proliferating epithelial cells. CONCLUSIONS: We conclude that SOX9 is required 
      for the differentiation of Paneth cells. Our results elucidate an essential step 
      in the differentiation of gut epithelium.
FAU - Mori-Akiyama, Yuko
AU  - Mori-Akiyama Y
AD  - Department of Molecular Geneticsm, The University of Texas, M. D. Anderson Cancer 
      Center, Houston, Texas, USA.
FAU - van den Born, Maaike
AU  - van den Born M
FAU - van Es, Johan H
AU  - van Es JH
FAU - Hamilton, Stanley R
AU  - Hamilton SR
FAU - Adams, Henry P
AU  - Adams HP
FAU - Zhang, Jiexin
AU  - Zhang J
FAU - Clevers, Hans
AU  - Clevers H
FAU - de Crombrugghe, Benoit
AU  - de Crombrugghe B
LA  - eng
GR  - CA16672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070521
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (SOX9 Transcription Factor)
RN  - 0 (Sox9 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
CIN - Gastroenterology. 2007 Aug;133(2):710-2. doi: 10.1053/j.gastro.2007.06.029. PMID: 
      17681188
MH  - Animals
MH  - *Cell Differentiation
MH  - Cell Proliferation
MH  - Epithelial Cells/*metabolism
MH  - High Mobility Group Proteins/deficiency/genetics/*metabolism
MH  - Intestinal Mucosa/cytology/growth & development/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Microvilli/metabolism
MH  - Paneth Cells/*metabolism
MH  - Phenotype
MH  - SOX9 Transcription Factor
MH  - Time Factors
MH  - Transcription Factors/deficiency/genetics/*metabolism
EDAT- 2007/08/08 09:00
MHDA- 2007/09/07 09:00
CRDT- 2007/08/08 09:00
PHST- 2006/10/24 00:00 [received]
PHST- 2007/05/03 00:00 [accepted]
PHST- 2007/08/08 09:00 [pubmed]
PHST- 2007/09/07 09:00 [medline]
PHST- 2007/08/08 09:00 [entrez]
AID - S0016-5085(07)01003-7 [pii]
AID - 10.1053/j.gastro.2007.05.020 [doi]
PST - ppublish
SO  - Gastroenterology. 2007 Aug;133(2):539-46. doi: 10.1053/j.gastro.2007.05.020. Epub 
      2007 May 21.