PMID- 17703228
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20231120
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 7
IP  - 9
DP  - 2007 Sep
TI  - FcRn: the neonatal Fc receptor comes of age.
PG  - 715-25
AB  - The neonatal Fc receptor for IgG (FcRn) has been well characterized in the 
      transfer of passive humoral immunity from a mother to her fetus. In addition, 
      throughout life, FcRn protects IgG from degradation, thereby explaining the long 
      half-life of this class of antibody in the serum. In recent years, it has become 
      clear that FcRn is expressed in various sites in adults, where its potential 
      function is now beginning to emerge. In addition, recent studies have examined 
      the interaction between FcRn and the Fc portion of IgG with the aim of either 
      improving the serum half-life of therapeutic monoclonal antibodies or reducing 
      the half-life of pathogenic antibodies. This Review summarizes these two areas of 
      FcRn biology.
FAU - Roopenian, Derry C
AU  - Roopenian DC
AD  - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. 
      dcr@jax.org
FAU - Akilesh, Shreeram
AU  - Akilesh S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070817
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Fc)
RN  - TW3XAW0RCY (Fc receptor, neonatal)
SB  - IM
MH  - Age Factors
MH  - Antigen-Presenting Cells/immunology
MH  - Blood-Brain Barrier/immunology
MH  - Histocompatibility Antigens Class I/chemistry/genetics/*metabolism
MH  - Humans
MH  - Immunity, Maternally-Acquired/*immunology
MH  - Immunoglobulin G/immunology
MH  - Protein Conformation
MH  - Receptors, Fc/chemistry/genetics/*metabolism
MH  - Tissue Distribution
RF  - 101
EDAT- 2007/08/19 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - nri2155 [pii]
AID - 10.1038/nri2155 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2007 Sep;7(9):715-25. doi: 10.1038/nri2155. Epub 2007 Aug 17.