PMID- 17703237
OWN - NLM
STAT- MEDLINE
DCOM- 20070924
LR  - 20190606
IS  - 1471-0056 (Print)
IS  - 1471-0056 (Linking)
VI  - 8
IP  - 9
DP  - 2007 Sep
TI  - The Decapentaplegic morphogen gradient: from pattern formation to growth 
      regulation.
PG  - 663-74
AB  - Morphogens have been linked to numerous developmental processes, including organ 
      patterning and the control of organ size. Here we review how different 
      experimental approaches have led to an unprecedented level of molecular knowledge 
      about the patterning role of the Drosophila melanogaster morphogen 
      Decapentaplegic (DPP, the homologue of vertebrate bone morphogenetic protein, or 
      BMP), the first validated secreted morphogen. In addition, we discuss how little 
      is known about the role of the DPP morphogen in the control of organ growth and 
      organ size. Continued efforts to elucidate the role of DPP in D. melanogaster is 
      likely to shed light on this fundamental question in the near future.
FAU - Affolter, Markus
AU  - Affolter M
AD  - Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH-4056 Basel, 
      Switzerland. markus.affolter@unibas.ch
FAU - Basler, Konrad
AU  - Basler K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (brk protein, Drosophila)
RN  - 0 (dpp protein, Drosophila)
RN  - 0 (shn protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Body Patterning/*genetics
MH  - Bone Morphogenetic Proteins/metabolism/physiology
MH  - DNA-Binding Proteins/physiology
MH  - Drosophila Proteins/*metabolism/*physiology
MH  - Drosophila melanogaster/*embryology/genetics
MH  - Embryo, Nonmammalian
MH  - Gene Expression Regulation, Developmental
MH  - Growth and Development/*genetics
MH  - Humans
MH  - Models, Biological
MH  - Morphogenesis/genetics
MH  - Repressor Proteins/physiology
MH  - Signal Transduction
MH  - Transcription Factors/physiology
RF  - 90
EDAT- 2007/08/19 09:00
MHDA- 2007/09/25 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/09/25 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - nrg2166 [pii]
AID - 10.1038/nrg2166 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2007 Sep;8(9):663-74. doi: 10.1038/nrg2166.