PMID- 18001039
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20220408
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 55
IP  - 25
DP  - 2007 Dec 12
TI  - Effect of curcumin on inflammation and oxidative stress in cisplatin-induced 
      experimental nephrotoxicity.
PG  - 10150-5
AB  - Nephrotoxicity is a major complication and a dose limiting factor for cisplatin 
      therapy. Recent evidence suggests that inflammation and oxidative stress may 
      contribute to the pathogenesis of cisplatin-induced acute renal failure. Curcumin 
      is claimed to be a potent anti-inflammatory and antioxidant agent. The present 
      study was performed to explore the effect of curcumin against cisplatin-induced 
      experimental nephrotoxicity. Curcumin in the dosages of 15, 30, and 60 mg kg(-1) 
      was administered 2 days before and 3 days after cisplatin administration. Renal 
      injury was assessed by measuring serum creatinine, blood urea nitrogen, 
      creatinine, urea clearance, and serum nitrite levels. Renal oxidative stress was 
      assessed by determining renal malondialdehyde levels, reduced glutathione levels 
      and enzymatic activities of superoxide dismutase and catalase. Systemic 
      inflammation was assessed by tumor necrosis factor-alpha (TNF-alpha) levels. A 
      single dose of cisplatin resulted in marked inflammation (486% rise in TNF-alpha 
      level) and oxidative stress and significantly deranged renal functions as well as 
      renal morphology. The serum TNF-alpha level was markedly reduced in 
      curcumin-treated rats. Curcumin treatment significantly and dose-dependently 
      restored renal function, reduced lipid peroxidation, and enhanced the levels of 
      reduced glutathione and activities of superoxide dismutase and catalase. The 
      present study demonstrates that curcumin has a protective effect on 
      cisplatin-induced experimental nephrotoxicity, and this effect is attributed to 
      its direct anti-inflammatory and strong antioxidant profile. Hence, curcumin has 
      a strong potential to be used as a therapeutic adjuvant in cisplatin 
      nephrotoxicity.
FAU - Kuhad, Anurag
AU  - Kuhad A
AD  - Pharmacology Research Laboratory, University Institute of Pharmaceutical 
      Sciences, UGC Centre for Advanced Studies, Panjab University, Chandigarh-160014, 
      India.
FAU - Pilkhwal, Sangeeta
AU  - Pilkhwal S
FAU - Sharma, Sameer
AU  - Sharma S
FAU - Tirkey, Naveen
AU  - Tirkey N
FAU - Chopra, Kanwaljit
AU  - Chopra K
LA  - eng
PT  - Journal Article
DEP - 20071115
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IT942ZTH98 (Curcumin)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage
MH  - Antioxidants/administration & dosage
MH  - Cisplatin/*toxicity
MH  - Curcumin/*administration & dosage/therapeutic use
MH  - Inflammation/*prevention & control
MH  - Kidney Diseases/*chemically induced/metabolism/*prevention & control
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2007/11/16 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - 10.1021/jf0723965 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2007 Dec 12;55(25):10150-5. doi: 10.1021/jf0723965. Epub 2007 
      Nov 15.