PMID- 18086379
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20211020
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 212
IP  - 9-10
DP  - 2007
TI  - The molecular basis of macrophage fusion.
PG  - 785-93
AB  - Multinucleated giant cells (MGCs), characteristic of granulomatous infections as 
      well as multinucleated osteoclasts originate from fusion of macrophages. While 
      intracellular and viral membrane fusion have been studied in detail, much less is 
      known about the machinery which mediates cell-to-cell fusion, in particular 
      macrophage polykaryon formation. Several molecules have been implicated in this 
      process which may involve the action of multiple glycoproteins mediating membrane 
      attachment and fusion. Macrophage fusion can be induced by soluble mediators such 
      as cytokines and growth factors, even though several other stimuli may be 
      involved, especially for the induction of granuloma-associated giant cells. The 
      function of MGCs during granulomatous diseases is currently unknown. However, a 
      better understanding of the mechanistic basis of macrophage fusion may lead to a 
      better understanding of the function of MGCs found in granulomas.
FAU - Helming, Laura
AU  - Helming L
AD  - Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
FAU - Gordon, Siamon
AU  - Gordon S
LA  - eng
GR  - G0600727/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20071109
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Fusion Regulatory Protein-1)
RN  - 0 (Membrane Proteins)
RN  - 0 (P2RX7 protein, human)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Purinergic P2)
RN  - 0 (Receptors, Purinergic P2X7)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 3.4.24.- (ADAM Proteins)
SB  - IM
MH  - ADAM Proteins/metabolism
MH  - Animals
MH  - Cell Adhesion Molecules/metabolism
MH  - *Cell Fusion
MH  - Fusion Regulatory Protein-1/metabolism
MH  - Giant Cells/*physiology
MH  - Glycosylation
MH  - Granuloma/physiopathology
MH  - Humans
MH  - Interleukin-4/metabolism
MH  - Macrophages/*physiology
MH  - Membrane Proteins/metabolism
MH  - Osteoclasts/physiology
MH  - Receptors, Chemokine/metabolism
MH  - Receptors, Purinergic P2/metabolism
MH  - Receptors, Purinergic P2X7
RF  - 73
EDAT- 2007/12/19 09:00
MHDA- 2008/03/15 09:00
CRDT- 2007/12/19 09:00
PHST- 2007/09/28 00:00 [received]
PHST- 2007/09/28 00:00 [accepted]
PHST- 2007/12/19 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2007/12/19 09:00 [entrez]
AID - S0171-2985(07)00118-0 [pii]
AID - 10.1016/j.imbio.2007.09.012 [doi]
PST - ppublish
SO  - Immunobiology. 2007;212(9-10):785-93. doi: 10.1016/j.imbio.2007.09.012. Epub 2007 
      Nov 9.