PMID- 18092947
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20211020
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Linking)
VI  - 409
IP  - 2
DP  - 2008 Jan 15
TI  - The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory 
      factor in vascular disease.
PG  - 349-55
AB  - Scavenger receptors are membrane glycoproteins that bind diverse ligands 
      including lipid particles, phospholipids, apoptotic cells and pathogens. LOX-1 
      (lectin-like oxidized low-density lipoprotein receptor-1) is increasingly linked 
      to atherosclerotic plaque formation. Transgenic mouse models for LOX-1 
      overexpression or gene knockout suggests that LOX-1 contributes to 
      atherosclerotic plaque formation and progression. LOX-1 activation by oxidized 
      LDL (low-density lipoprotein) binding stimulates intracellular signalling, gene 
      expression and production of superoxide radicals. A key question is the role of 
      leucocyte LOX-1 in pro-atherogenic lipid particle trafficking, accumulation and 
      signalling leading to differentiation into foam cells, necrosis and plaque 
      development. LOX-1 expression is elevated within vascular lesions and a serum 
      soluble LOX-1 fragment appears diagnostic of patients with acute coronary 
      syndromes. LOX-1 is increasingly viewed as a vascular disease biomarker and a 
      potential therapeutic target in heart attack and stroke prevention.
FAU - Dunn, Sarah
AU  - Dunn S
AD  - Endothelial Cell Biology Unit, Leeds Institute of Genetics, Health and 
      Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK.
FAU - Vohra, Ravinder S
AU  - Vohra RS
FAU - Murphy, Jane E
AU  - Murphy JE
FAU - Homer-Vanniasinkam, Shervanthi
AU  - Homer-Vanniasinkam S
FAU - Walker, John H
AU  - Walker JH
FAU - Ponnambalam, Sreenivasan
AU  - Ponnambalam S
LA  - eng
GR  - PG/06/141/21879/BHF_/British Heart Foundation/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Biomarkers)
RN  - 0 (Ligands)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Scavenger Receptors, Class E)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*metabolism
MH  - Biomarkers
MH  - Humans
MH  - Inflammation/metabolism
MH  - Ligands
MH  - Lipoproteins, LDL/metabolism
MH  - Mice
MH  - Models, Animal
MH  - Protein Transport
MH  - Scavenger Receptors, Class E/chemistry/genetics/*metabolism
MH  - Signal Transduction
RF  - 63
EDAT- 2007/12/21 09:00
MHDA- 2008/02/13 09:00
CRDT- 2007/12/21 09:00
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
AID - BJ20071196 [pii]
AID - 10.1042/BJ20071196 [doi]
PST - ppublish
SO  - Biochem J. 2008 Jan 15;409(2):349-55. doi: 10.1042/BJ20071196.