PMID- 18094723
OWN - NLM
STAT- MEDLINE
DCOM- 20080221
LR  - 20220330
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 8
IP  - 2
DP  - 2008 Feb
TI  - FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, 
      growth and differentiation.
PG  - 83-93
AB  - FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition 
      component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box 
      protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that 
      function in cellular growth and division pathways, including MYC, cyclin E, Notch 
      and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is 
      perturbed in many human malignancies. Numerous cancer-associated mutations in 
      FBW7 and its substrates have been identified, and loss of FBW7 function causes 
      chromosomal instability and tumorigenesis. This Review focuses on structural and 
      functional aspects of FBW7 and its role in the development of cancer.
FAU - Welcker, Markus
AU  - Welcker M
AD  - Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview 
      Avenue North, Seattle, Washington 98109, USA. mwelcker@fhcrc.org
FAU - Clurman, Bruce E
AU  - Clurman BE
LA  - eng
GR  - P01 HL084205/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin E)
RN  - 0 (F-Box Proteins)
RN  - 0 (F-Box-WD Repeat-Containing Protein 7)
RN  - 0 (FBXW7 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins/*physiology
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Proliferation
MH  - Cyclin E/metabolism
MH  - Dimerization
MH  - F-Box Proteins/*physiology
MH  - F-Box-WD Repeat-Containing Protein 7
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mice
MH  - Models, Biological
MH  - Mutation
MH  - Neoplasms/metabolism/*pathology
MH  - Ubiquitin-Protein Ligases/*physiology
RF  - 119
EDAT- 2007/12/21 09:00
MHDA- 2008/02/22 09:00
CRDT- 2007/12/21 09:00
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/02/22 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
AID - nrc2290 [pii]
AID - 10.1038/nrc2290 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2008 Feb;8(2):83-93. doi: 10.1038/nrc2290.