PMID- 18097445
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20240109
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 9
IP  - 1
DP  - 2008 Jan
TI  - The BCL-2 protein family: opposing activities that mediate cell death.
PG  - 47-59
AB  - BCL-2 family proteins, which have either pro- or anti-apoptotic activities, have 
      been studied intensively for the past decade owing to their importance in the 
      regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer 
      therapy. They control the point of no return for clonogenic cell survival and 
      thereby affect tumorigenesis and host-pathogen interactions and regulate animal 
      development. Recent structural, phylogenetic and biological analyses, however, 
      suggest the need for some reconsideration of the accepted organizational 
      principles of the family and how the family members interact with one another 
      during programmed cell death. Although these insights into interactions among 
      BCL-2 family proteins reveal how these proteins are regulated, a unifying 
      hypothesis for the mechanisms they use to activate caspases remains elusive.
FAU - Youle, Richard J
AU  - Youle RJ
AD  - Biochemistry Section, Surgical Neurology Branch, National Institute of 
      Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, 
      Maryland 20892, USA. youler@ninds.nih.gov
FAU - Strasser, Andreas
AU  - Strasser A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Humans
MH  - Mitochondria/physiology
MH  - Models, Molecular
MH  - Phylogeny
MH  - Protein Structure, Tertiary/physiology
MH  - Proto-Oncogene Proteins c-bcl-2/*physiology
RF  - 166
EDAT- 2007/12/22 09:00
MHDA- 2008/01/11 09:00
CRDT- 2007/12/22 09:00
PHST- 2007/12/22 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/12/22 09:00 [entrez]
AID - nrm2308 [pii]
AID - 10.1038/nrm2308 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. doi: 10.1038/nrm2308.