PMID- 18097458
OWN - NLM
STAT- MEDLINE
DCOM- 20080305
LR  - 20220408
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 7
IP  - 1
DP  - 2008 Jan
TI  - Protein therapeutics: a summary and pharmacological classification.
PG  - 21-39
AB  - Once a rarely used subset of medical treatments, protein therapeutics have 
      increased dramatically in number and frequency of use since the introduction of 
      the first recombinant protein therapeutic--human insulin--25 years ago. Protein 
      therapeutics already have a significant role in almost every field of medicine, 
      but this role is still only in its infancy. This article overviews some of the 
      key characteristics of protein therapeutics, summarizes the more than 130 protein 
      therapeutics used currently and suggests a new classification of these proteins 
      according to their pharmacological action.
FAU - Leader, Benjamin
AU  - Leader B
AD  - Department of Emergency Medicine, Brown Medical School, 593 Eddy Street, 
      Providence, Rhode Island 02093, USA.
FAU - Baca, Quentin J
AU  - Baca QJ
FAU - Golan, David E
AU  - Golan DE
LA  - eng
GR  - T32 GM007753/GM/NIGMS NIH HHS/United States
GR  - R37HL032854/HL/NHLBI NIH HHS/United States
GR  - U54HL070819/HL/NHLBI NIH HHS/United States
GR  - T32GM07753/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Insulin)
RN  - 0 (Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
RN  - 15UQ94PT4P (Darbepoetin alfa)
SB  - IM
MH  - Cystic Fibrosis/drug therapy/genetics
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/genetics/therapeutic use
MH  - Darbepoetin alfa
MH  - Diabetes Mellitus/drug therapy
MH  - Erythropoietin/analogs & derivatives/therapeutic use
MH  - Humans
MH  - Insulin/therapeutic use
MH  - Protein Deficiency/drug therapy
MH  - Proteins/*therapeutic use
MH  - Recombinant Proteins/*therapeutic use
RF  - 300
EDAT- 2007/12/22 09:00
MHDA- 2008/03/06 09:00
CRDT- 2007/12/22 09:00
PHST- 2007/12/22 09:00 [pubmed]
PHST- 2008/03/06 09:00 [medline]
PHST- 2007/12/22 09:00 [entrez]
AID - nrd2399 [pii]
AID - 10.1038/nrd2399 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2008 Jan;7(1):21-39. doi: 10.1038/nrd2399.