PMID- 18157115
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20231024
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 451
IP  - 7175
DP  - 2008 Jan 10
TI  - Reprogramming of human somatic cells to pluripotency with defined factors.
PG  - 141-6
AB  - Pluripotency pertains to the cells of early embryos that can generate all of the 
      tissues in the organism. Embryonic stem cells are embryo-derived cell lines that 
      retain pluripotency and represent invaluable tools for research into the 
      mechanisms of tissue formation. Recently, murine fibroblasts have been 
      reprogrammed directly to pluripotency by ectopic expression of four transcription 
      factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells. 
      Using these same factors, we have derived iPS cells from fetal, neonatal and 
      adult human primary cells, including dermal fibroblasts isolated from a skin 
      biopsy of a healthy research subject. Human iPS cells resemble embryonic stem 
      cells in morphology and gene expression and in the capacity to form teratomas in 
      immune-deficient mice. These data demonstrate that defined factors can 
      reprogramme human cells to pluripotency, and establish a method whereby 
      patient-specific cells might be established in culture.
FAU - Park, In-Hyun
AU  - Park IH
AD  - Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana 
      Farber Cancer Institute, Boston, Massachusetts 02115, USA.
FAU - Zhao, Rui
AU  - Zhao R
FAU - West, Jason A
AU  - West JA
FAU - Yabuuchi, Akiko
AU  - Yabuuchi A
FAU - Huo, Hongguang
AU  - Huo H
FAU - Ince, Tan A
AU  - Ince TA
FAU - Lerou, Paul H
AU  - Lerou PH
FAU - Lensch, M William
AU  - Lensch MW
FAU - Daley, George Q
AU  - Daley GQ
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071223
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HMGB Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (MYC protein, human)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Sox2 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
CIN - Nature. 2008 Jan 10;451(7175):135-6. PMID: 18185576
MH  - Adult
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Shape
MH  - Cells, Cultured
MH  - DNA Methylation
MH  - DNA-Binding Proteins/genetics
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Fetus/cytology
MH  - Fibroblasts/cytology
MH  - Gene Expression Profiling
MH  - HMGB Proteins/genetics/*metabolism
MH  - Homeodomain Proteins/genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/*metabolism
MH  - Mice
MH  - Nanog Homeobox Protein
MH  - Octamer Transcription Factor-3/genetics/*metabolism
MH  - Pluripotent Stem Cells/*cytology/*metabolism/transplantation
MH  - Promoter Regions, Genetic/genetics
MH  - Proto-Oncogene Proteins c-myc/genetics/*metabolism
MH  - SOXB1 Transcription Factors
MH  - Teratoma/pathology
MH  - Transcription Factors/genetics/*metabolism
MH  - Transplantation, Heterologous
EDAT- 2007/12/25 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/12/25 09:00
PHST- 2007/11/16 00:00 [received]
PHST- 2007/12/10 00:00 [accepted]
PHST- 2007/12/25 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/12/25 09:00 [entrez]
AID - nature06534 [pii]
AID - 10.1038/nature06534 [doi]
PST - ppublish
SO  - Nature. 2008 Jan 10;451(7175):141-6. doi: 10.1038/nature06534. Epub 2007 Dec 23.