PMID- 18161758
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20230112
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 214
IP  - 2
DP  - 2008 Jan
TI  - Immune activation and inflammation in HIV-1 infection: causes and consequences.
PG  - 231-41
AB  - Thorough research on HIV is progressively enabling us to understand the intricate 
      mechanisms that link HIV-1 infection to the onset of immunodeficiency. The 
      infection and depletion of CD4(+) T cells represent the most fundamental events 
      in HIV-1 infection. However, in recent years, the role played by chronic immune 
      activation and inflammation in HIV pathogenesis has become increasingly apparent: 
      quite paradoxically, immune activation levels are directly associated with HIV-1 
      disease progression. In addition, HIV-1-infected patients present intriguing 
      similarities with individuals of old age: their immune systems are characterized 
      by a loss of regenerative capacity and an accumulation of ageing T cells. In this 
      review, we discuss the potential reasons for the establishment of sustained 
      immune activation and inflammation from the early stages of HIV-1 infection, as 
      well as the long-term consequences of this process on the host immune system and 
      health. A simplified model of HIV pathogenesis is proposed, which links together 
      the three major facets of HIV-1 infection: the massive depletion of CD4(+) T 
      cells, the paradoxical immune activation and the exhaustion of regenerative 
      capacity.
CI  - 2007 Pathological Society of Great Britain and Ireland
FAU - Appay, V
AU  - Appay V
AD  - Cellular Immunology Laboratory, INSERM U543, Hopital Pitie-Salpetriere, 
      Universite Pierre et Marie Curie-Paris6, Paris, France. 
      victor.appay@chups.jussieu.fr
FAU - Sauce, D
AU  - Sauce D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
SB  - IM
MH  - Aging/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Disease Progression
MH  - HIV Infections/*immunology
MH  - *HIV-1
MH  - Humans
MH  - Inflammation/*immunology
MH  - Lymphocyte Activation/*immunology
MH  - Models, Immunological
RF  - 149
EDAT- 2007/12/29 09:00
MHDA- 2008/03/22 09:00
CRDT- 2007/12/29 09:00
PHST- 2007/12/29 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2007/12/29 09:00 [entrez]
AID - 10.1002/path.2276 [doi]
PST - ppublish
SO  - J Pathol. 2008 Jan;214(2):231-41. doi: 10.1002/path.2276.