PMID- 18167337
OWN - NLM
STAT- MEDLINE
DCOM- 20080206
LR  - 20211203
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 13
IP  - 1
DP  - 2008 Jan
TI  - Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ 
      myeloid cells that promote metastasis.
PG  - 23-35
LID - 10.1016/j.ccr.2007.12.004 [doi]
AB  - Aberrant TGFbeta signaling is common in human cancers and contributes to tumor 
      metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited 
      into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and 
      directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate into the invasive 
      front of tumor tissues and facilitate tumor cell invasion and metastasis through 
      a process involving metalloproteinase activity. This infiltration of Gr-1+CD11b+ 
      cells also results in increased abundance of TGF beta 1 in tumors with Tgfbr2 
      deletion. The recruitment of Gr-1+CD11b+ cells into tumors with Tgfbr2 deletion 
      involves two chemokine receptor axes, the SDF-1/CXCR4 and CXCL5/CXCR2 axes. 
      Together, these data indicate that Gr-1+CD11b+ cells contribute to 
      TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis.
FAU - Yang, Li
AU  - Yang L
AD  - Department of Cancer Biology, Vanderbilt University School of Medicine, 
      Nashville, TN 37232, USA. li.yang@vanderbilt.edu
FAU - Huang, Jianhua
AU  - Huang J
FAU - Ren, Xiubao
AU  - Ren X
FAU - Gorska, Agnieszka E
AU  - Gorska AE
FAU - Chytil, Anna
AU  - Chytil A
FAU - Aakre, Mary
AU  - Aakre M
FAU - Carbone, David P
AU  - Carbone DP
FAU - Matrisian, Lynn M
AU  - Matrisian LM
FAU - Richmond, Ann
AU  - Richmond A
FAU - Lin, P Charles
AU  - Lin PC
FAU - Moses, Harold L
AU  - Moses HL
LA  - eng
GR  - R01 CA108856/CA/NCI NIH HHS/United States
GR  - R01 CA116021-04/CA/NCI NIH HHS/United States
GR  - P30 DK058404/DK/NIDDK NIH HHS/United States
GR  - 5P50CA098131/CA/NCI NIH HHS/United States
GR  - CA085492/CA/NCI NIH HHS/United States
GR  - R01 CA116021-03/CA/NCI NIH HHS/United States
GR  - P50 CA098131/CA/NCI NIH HHS/United States
GR  - U54 CA126505/CA/NCI NIH HHS/United States
GR  - P30 CA068485/CA/NCI NIH HHS/United States
GR  - R01 CA116021/CA/NCI NIH HHS/United States
GR  - CA108856/CA/NCI NIH HHS/United States
GR  - CA102162/CA/NCI NIH HHS/United States
GR  - IK6 BX005225/BX/BLRD VA/United States
GR  - R01 CA034590-24/CA/NCI NIH HHS/United States
GR  - R01 CA102162/CA/NCI NIH HHS/United States
GR  - R01 CA034590/CA/NCI NIH HHS/United States
GR  - R01 CA034590-25A1/CA/NCI NIH HHS/United States
GR  - R01 CA034590-26/CA/NCI NIH HHS/United States
GR  - R01 CA076321/CA/NCI NIH HHS/United States
GR  - CA126505/CA/NCI NIH HHS/United States
GR  - R01 CA085492/CA/NCI NIH HHS/United States
GR  - R01 CA076321-10/CA/NCI NIH HHS/United States
GR  - CA068485/CA/NCI NIH HHS/United States
GR  - P30 DK58404/DK/NIDDK NIH HHS/United States
GR  - R01 CA108856-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (CD11b Antigen)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.30 (Receptor, Transforming Growth Factor-beta Type II)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/enzymology/*metabolism/*pathology
MH  - CD11b Antigen/*metabolism
MH  - Cell Line, Tumor
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - Matrix Metalloproteinases/biosynthesis
MH  - Mice
MH  - Models, Biological
MH  - Myeloid Cells/enzymology/*pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Receptor, Transforming Growth Factor-beta Type II
MH  - Receptors, Transforming Growth Factor beta/metabolism
MH  - *Signal Transduction
MH  - Transforming Growth Factor beta/*metabolism
PMC - PMC2245859
MID - NIHMS37354
EDAT- 2008/01/03 09:00
MHDA- 2008/02/07 09:00
PMCR- 2008/02/15
CRDT- 2008/01/03 09:00
PHST- 2007/03/02 00:00 [received]
PHST- 2007/08/06 00:00 [revised]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/01/03 09:00 [pubmed]
PHST- 2008/02/07 09:00 [medline]
PHST- 2008/01/03 09:00 [entrez]
PHST- 2008/02/15 00:00 [pmc-release]
AID - S1535-6108(07)00373-X [pii]
AID - 10.1016/j.ccr.2007.12.004 [doi]
PST - ppublish
SO  - Cancer Cell. 2008 Jan;13(1):23-35. doi: 10.1016/j.ccr.2007.12.004.