PMID- 18180878
OWN - NLM
STAT- MEDLINE
DCOM- 20080411
LR  - 20080125
IS  - 0167-7659 (Print)
IS  - 0167-7659 (Linking)
VI  - 27
IP  - 1
DP  - 2008 Mar
TI  - The selectin-selectin ligand axis in tumor progression.
PG  - 19-30
LID - 10.1007/s10555-007-9101-z [doi]
AB  - This review will document that the selectin-selectin ligand axis is actively 
      involved in tumor progression and drives this process. The involvement of 
      selectins and their ligands in tumor progression takes place at three levels 
      which will be reviewed: Interaction of tumor cells with platelets and leukocytes 
      resulting in the formation of circulating emboli; interaction of tumor cells with 
      endothelial cells leading to extravasation of the tumor cells; and utilization of 
      reciprocal pro malignancy signals delivered by the selectins or by their ligands 
      to interacting cells that express the corresponding co-receptor. We propose that 
      the selectin-selectin ligand mediated interactions between cells in the tumor 
      microenvironment constitute an axis of evil, that it be included in the list of 
      pro malignancy factors, and that molecules associated with this axis serve as 
      targets for cancer therapy.
FAU - Witz, Isaac P
AU  - Witz IP
AD  - Department of Cell Research and Immunology, The George S. Wise Faculty of Life 
      Sciences, Tel Aviv University, Tel Aviv, 69978, Israel. isaacw@tauex.tau.ac.il
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Cancer Metastasis Rev
JT  - Cancer metastasis reviews
JID - 8605731
RN  - 0 (Ligands)
RN  - 0 (Selectins)
SB  - IM
MH  - Cell Communication
MH  - Cell Movement
MH  - Cell Transformation, Neoplastic
MH  - Disease Progression
MH  - Humans
MH  - Ligands
MH  - Neoplasms/*metabolism
MH  - Selectins/*physiology
RF  - 166
EDAT- 2008/01/09 09:00
MHDA- 2008/04/12 09:00
CRDT- 2008/01/09 09:00
PHST- 2008/01/09 09:00 [pubmed]
PHST- 2008/04/12 09:00 [medline]
PHST- 2008/01/09 09:00 [entrez]
AID - 10.1007/s10555-007-9101-z [doi]
PST - ppublish
SO  - Cancer Metastasis Rev. 2008 Mar;27(1):19-30. doi: 10.1007/s10555-007-9101-z.