PMID- 18192061
OWN - NLM
STAT- MEDLINE
DCOM- 20080502
LR  - 20220321
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Linking)
VI  - 24
IP  - 2
DP  - 2008 Feb
TI  - Defining 'chromosomal instability'.
PG  - 64-9
LID - 10.1016/j.tig.2007.11.006 [doi]
AB  - Most scientists agree that the majority of human solid malignant tumors are 
      characterized by chromosomal instability (CIN) involving gain or loss of whole 
      chromosomes or fractions of chromosomes. CIN is thought to be an early event 
      during tumorigenesis and might therefore be involved in tumor initiation. Despite 
      its frequent occurrence in tumors and its potential importance in tumor 
      evolution, CIN is poorly defined and is used inconsistently and imprecisely. 
      Here, we provide criteria to define CIN and argue that few experimental 
      approaches are capable of assessing the presence of CIN. Accurate assessment of 
      CIN is crucial to elucidate whether CIN is a driving force for tumorigenesis and 
      whether a chromosomally unstable genome is necessary for tumor progression.
FAU - Geigl, Jochen B
AU  - Geigl JB
AD  - Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria.
FAU - Obenauf, Anna C
AU  - Obenauf AC
FAU - Schwarzbraun, Thomas
AU  - Schwarzbraun T
FAU - Speicher, Michael R
AU  - Speicher MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080114
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
SB  - IM
MH  - Aneuploidy
MH  - *Chromosomal Instability
MH  - Genetic Techniques
MH  - Genomic Instability
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Loss of Heterozygosity
MH  - Neoplasms/genetics
MH  - Nucleic Acid Hybridization
MH  - Polyploidy
RF  - 47
EDAT- 2008/01/15 09:00
MHDA- 2008/05/03 09:00
CRDT- 2008/01/15 09:00
PHST- 2007/09/18 00:00 [received]
PHST- 2007/11/16 00:00 [revised]
PHST- 2007/11/20 00:00 [accepted]
PHST- 2008/01/15 09:00 [pubmed]
PHST- 2008/05/03 09:00 [medline]
PHST- 2008/01/15 09:00 [entrez]
AID - S0168-9525(07)00384-8 [pii]
AID - 10.1016/j.tig.2007.11.006 [doi]
PST - ppublish
SO  - Trends Genet. 2008 Feb;24(2):64-9. doi: 10.1016/j.tig.2007.11.006. Epub 2008 Jan 
      14.