PMID- 18192062
OWN - NLM
STAT- MEDLINE
DCOM- 20080502
LR  - 20080204
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Linking)
VI  - 24
IP  - 2
DP  - 2008 Feb
TI  - Interstrand crosslink repair: can XPF-ERCC1 be let off the hook?
PG  - 70-6
LID - 10.1016/j.tig.2007.11.003 [doi]
AB  - The interstrand crosslink (ICL) presents a challenge to both the cell and the 
      scientist. From a clinical standpoint, these lesions are particularly intriguing: 
      ICL-inducing agents are powerful tools in cancer chemotherapy, and spontaneous 
      ICLs have recently been linked with accelerated aging phenotypes. Nevertheless, 
      the ICL repair process has proven difficult to elucidate. Here we discuss recent 
      additions to the current model and argue that the endonuclease xeroderma 
      pigmentosum complementation group F-excision repair cross-complementing rodent 
      repair deficiency complementation group 1 (XPF-ERCC1) has been heretofore 
      misplaced. During nucleotide excision repair, XPF-ERCC1 makes a single-strand 
      nick adjacent to the lesion. XPF-ERCC1 has been thought to play an analogous role 
      in ICL repair. However, recent data has implicated XPF-ERCC1 in homologous 
      recombination. We suggest that this role, rather than its function in nucleotide 
      excision repair, defines its importance to ICL repair.
FAU - Bergstralh, Daniel T
AU  - Bergstralh DT
AD  - Department of Biology, Program in Molecular Biology and Biotechnology, and 
      Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel 
      Hill, NC 27599, USA.
FAU - Sekelsky, Jeff
AU  - Sekelsky J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080114
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (xeroderma pigmentosum group F protein)
RN  - EC 3.1.- (ERCC1 protein, human)
RN  - EC 3.1.- (Endonucleases)
SB  - IM
MH  - Animals
MH  - DNA Breaks, Double-Stranded
MH  - DNA Repair/genetics/*physiology
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Endonucleases/genetics/*metabolism
MH  - Genetic Complementation Test
MH  - Humans
MH  - Models, Biological
MH  - Recombination, Genetic
MH  - Xeroderma Pigmentosum/genetics/metabolism
RF  - 67
EDAT- 2008/01/15 09:00
MHDA- 2008/05/03 09:00
CRDT- 2008/01/15 09:00
PHST- 2007/09/28 00:00 [received]
PHST- 2007/11/16 00:00 [revised]
PHST- 2007/11/19 00:00 [accepted]
PHST- 2008/01/15 09:00 [pubmed]
PHST- 2008/05/03 09:00 [medline]
PHST- 2008/01/15 09:00 [entrez]
AID - S0168-9525(07)00387-3 [pii]
AID - 10.1016/j.tig.2007.11.003 [doi]
PST - ppublish
SO  - Trends Genet. 2008 Feb;24(2):70-6. doi: 10.1016/j.tig.2007.11.003. Epub 2008 Jan 
      14.