PMID- 18196925
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20080709
IS  - 1422-6421 (Electronic)
IS  - 1422-6405 (Linking)
VI  - 188
IP  - 1-2
DP  - 2008
TI  - Notch signaling in embryonic and adult myelopoiesis.
PG  - 91-102
LID - 10.1159/000113531 [doi]
AB  - Notch signaling is a highly conserved mechanism of intercellular communication 
      that controls the developmental fate in all animal species studied to date. 
      Specific transmembrane ligands activate Notch receptors on neighboring cells, 
      thereby inducing proteolytic cleavage and nuclear translocation of the Notch 
      intracellular domain (Notch(IC)). Notch(IC) associates with the transcriptional 
      repressor RBP-J (recombination recognition sequence binding protein at the J 
      kappa site), also known as CSL [CBF1/Su(H)/Lag-1], and converts it to an 
      activator. In conjunction with chromatin remodeling enzymes, components of the 
      transcriptional machinery and the activity of other cofactors, Notch(IC) induces 
      transcription of downstream target genes, including genes of the Hes (hairy and 
      enhancer of split) and Hey (also called Hes-related repressor Herp, Hesr, Hrt, 
      CHF, gridlock) family. Recent evidence has shown that the Notch pathway is 
      involved in multiple aspects of hematopoietic development. In this review, we 
      summarize the current knowledge of the components and mechanisms of the Notch 
      signaling pathway and discuss the role of Notch in embryonic and adult 
      myelopoiesis. Finally, we will focus on mediators of Notch signaling in the 
      hematopoietic system. We propose that besides suppression of differentiation 
      mediated by the Hes/Hey family, Notch/ RBP-J signaling mediates lineage decisions 
      by direct activation of transcription factors such as PU.1, that are critically 
      involved in directing cells along certain cell lineages, and further influences 
      maturation by activation of functional genes, for example beta-globin.
CI  - (c) 2008 S. Karger AG, Basel.
FAU - Schwanbeck, Ralf
AU  - Schwanbeck R
AD  - Department of Biochemistry, Christian-Albrechts-Universitat zu Kiel, Kiel, 
      Germany.
FAU - Schroeder, Timm
AU  - Schroeder T
FAU - Henning, Konstanze
AU  - Henning K
FAU - Kohlhof, Hella
AU  - Kohlhof H
FAU - Rieber, Nikolaus
AU  - Rieber N
FAU - Erfurth, Maria-Luise
AU  - Erfurth ML
FAU - Just, Ursula
AU  - Just U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080116
PL  - Switzerland
TA  - Cells Tissues Organs
JT  - Cells, tissues, organs
JID - 100883360
RN  - 0 (Receptors, Notch)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Embryo, Mammalian/*metabolism
MH  - Humans
MH  - *Myelopoiesis
MH  - Receptors, Notch/*metabolism
MH  - *Signal Transduction
RF  - 93
EDAT- 2008/01/17 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/01/17 09:00
PHST- 2008/01/17 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/01/17 09:00 [entrez]
AID - 000113531 [pii]
AID - 10.1159/000113531 [doi]
PST - ppublish
SO  - Cells Tissues Organs. 2008;188(1-2):91-102. doi: 10.1159/000113531. Epub 2008 Jan 
      16.