PMID- 18198151
OWN - NLM
STAT- MEDLINE
DCOM- 20080603
LR  - 20220129
IS  - 0962-8436 (Print)
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 363
IP  - 1495
DP  - 2008 Apr 12
TI  - Molecular analysis of neural crest migration.
PG  - 1349-62
LID - 10.1098/rstb.2007.2252 [doi]
AB  - The neural crest (NC) cells have been called the 'explorers of the embryos' 
      because they migrate all over the embryo where they differentiate into a variety 
      of diverse kinds of cells. In this work, we analyse the role of different 
      molecules controlling the migration of NC cells. First, we describe the strong 
      similarity between the process of NC migration and metastasis in tumour cells. 
      The epithelial-mesenchymal transition process that both kinds of cells undergo is 
      controlled by the same molecular machinery, including cadherins, connexins, Snail 
      and Twist genes and matrix metalloproteases. Second, we analysed the molecular 
      signals that control the patterned migration of the cephalic and trunk NC cells. 
      Most of the factors described so far, such as Eph/ephrins, 
      semaphorins/neuropilins and Slit/Robo, are negative signals that prohibit the 
      migration of NC cells into target areas of the embryo. Finally, we analyse how 
      the direction of migration is controlled by regulation of cell polarity and how 
      the planar cell polarity or non-canonical Wnt signalling is involved in this 
      process.
FAU - Kuriyama, Sei
AU  - Kuriyama S
AD  - Department of Anatomy and Developmental Biology, University College London, Gower 
      Street, London WC1E 6BT, UK.
FAU - Mayor, Roberto
AU  - Mayor R
LA  - eng
GR  - G117/506/MRC_/Medical Research Council/United Kingdom
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
SB  - IM
MH  - Animals
MH  - Body Patterning/*physiology
MH  - Cell Differentiation/*physiology
MH  - Cell Movement/*physiology
MH  - Cell Polarity/*physiology
MH  - Neoplasm Metastasis/*physiopathology
MH  - Neural Crest/*physiology
MH  - Signal Transduction/*physiology
PMC - PMC2610123
EDAT- 2008/01/17 09:00
MHDA- 2008/06/05 09:00
PMCR- 2009/04/12
CRDT- 2008/01/17 09:00
PHST- 2008/01/17 09:00 [pubmed]
PHST- 2008/06/05 09:00 [medline]
PHST- 2008/01/17 09:00 [entrez]
PHST- 2009/04/12 00:00 [pmc-release]
AID - P044788R26366Q29 [pii]
AID - rstb20072252 [pii]
AID - 10.1098/rstb.2007.2252 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2008 Apr 12;363(1495):1349-62. doi: 
      10.1098/rstb.2007.2252.