PMID- 18202698
OWN - NLM
STAT- MEDLINE
DCOM- 20080221
LR  - 20220408
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 8
IP  - 2
DP  - 2008 Feb
TI  - Translation of new cancer treatments from pet dogs to humans.
PG  - 147-56
LID - 10.1038/nrc2273 [doi]
AB  - Naturally occurring cancers in pet dogs and humans share many features, including 
      histological appearance, tumour genetics, molecular targets, biological behaviour 
      and response to conventional therapies. Studying dogs with cancer is likely to 
      provide a valuable perspective that is distinct from that generated by the study 
      of human or rodent cancers alone. The value of this opportunity has been 
      increasingly recognized in the field of cancer research for the identification of 
      cancer-associated genes, the study of environmental risk factors, understanding 
      tumour biology and progression, and, perhaps most importantly, the evaluation and 
      development of novel cancer therapeutics.
FAU - Paoloni, Melissa
AU  - Paoloni M
AD  - Comparative Oncology Program, Center for Cancer Research, National Cancer 
      Institute, 37 Convent Drive, Room 2144, Bethesda, Maryland 20892, USA.
FAU - Khanna, Chand
AU  - Khanna C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Clinical Trials as Topic
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Dogs
MH  - Humans
MH  - Medical Oncology/*methods
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Neoplasms/*pathology/*veterinary
MH  - Research Design
MH  - Risk Factors
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
RF  - 111
EDAT- 2008/01/19 09:00
MHDA- 2008/02/22 09:00
CRDT- 2008/01/19 09:00
PHST- 2008/01/19 09:00 [pubmed]
PHST- 2008/02/22 09:00 [medline]
PHST- 2008/01/19 09:00 [entrez]
AID - nrc2273 [pii]
AID - 10.1038/nrc2273 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2008 Feb;8(2):147-56. doi: 10.1038/nrc2273.