PMID- 18204970
OWN - NLM
STAT- MEDLINE
DCOM- 20080724
LR  - 20211109
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 33
IP  - 6
DP  - 2008 Jun
TI  - Anti-ischemic effect of curcumin in rat brain.
PG  - 1036-43
LID - 10.1007/s11064-007-9547-y [doi]
AB  - Turmeric has been in use since ancient times as a condiment and due to its 
      medicinal properties. Curcumin, the yellow colouring principle in turmeric, is 
      polyphenolic and major active constituent. Besides anti-inflammatory, 
      thrombolytic and anticarcinogenic activities, curcumin also possesses strong 
      antioxidant property. In view of the novel combination of properties, 
      neuroprotective efficacy of curcumin was studied in rat middle cerebral artery 
      occlusion (MCAO) model. Rats were subjected to 2 h of focal ischemia followed by 
      72 h of reperfusion. They were pre-treated with curcumin (100 mg/kg, po) for 5 
      days prior to MCAO and for another 3 days after MCAO. The parameters studied were 
      behavioural, biochemical and histological. Treatment with curcumin could 
      significantly improve neurobehavioral performance compared to untreated ischemic 
      rats as judged by its effect on rota-rod performance and grid walking. A 
      significant inhibition in lipid peroxidation and an increase in superoxide 
      dismutase (SOD) activity in corpus striatum and cerebral cortex was observed 
      following treatment with curcumin in MCAO rats as compared to MCAO group. 
      Intracellular calcium levels were decreased following treatment with curcumin in 
      MCAO rats. Histologically, a reduction in the infarct area from 33% to 24% was 
      observed in MCAO rats treated with curcumin. The study demonstrates the 
      protective efficacy of curcumin in rat MCAO model.
FAU - Shukla, Pradeep K
AU  - Shukla PK
AD  - Developmental Toxicology, Industrial Toxicology Research Centre, PO Box 80, MG 
      Marg, Lucknow 226 001, India.
FAU - Khanna, Vinay K
AU  - Khanna VK
FAU - Ali, Mohd M
AU  - Ali MM
FAU - Khan, Mohd Y
AU  - Khan MY
FAU - Srimal, Rikhab C
AU  - Srimal RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080118
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Neuroprotective Agents)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - IT942ZTH98 (Curcumin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/anatomy & histology/*drug effects
MH  - *Brain Ischemia/metabolism/prevention & control
MH  - Calcium/metabolism
MH  - Curcumin/*pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Humans
MH  - Infarction, Middle Cerebral Artery
MH  - Lipid Peroxidation
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
EDAT- 2008/01/22 09:00
MHDA- 2008/07/25 09:00
CRDT- 2008/01/22 09:00
PHST- 2006/02/17 00:00 [received]
PHST- 2007/11/08 00:00 [accepted]
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/07/25 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - 10.1007/s11064-007-9547-y [doi]
PST - ppublish
SO  - Neurochem Res. 2008 Jun;33(6):1036-43. doi: 10.1007/s11064-007-9547-y. Epub 2008 
      Jan 18.