PMID- 18227151
OWN - NLM
STAT- MEDLINE
DCOM- 20080501
LR  - 20240104
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 28
IP  - 7
DP  - 2008 Apr
TI  - TAZ promotes cell proliferation and epithelial-mesenchymal transition and is 
      inhibited by the hippo pathway.
PG  - 2426-36
LID - 10.1128/MCB.01874-07 [doi]
AB  - TAZ is a WW domain containing a transcription coactivator that modulates 
      mesenchymal differentiation and development of multiple organs. In this study, we 
      show that TAZ is phosphorylated by the Lats tumor suppressor kinase, a key 
      component of the Hippo pathway, whose alterations result in organ and tissue 
      hypertrophy in Drosophila and contribute to tumorigenesis in humans. Lats 
      phosphorylates TAZ on several serine residues in the conserved HXRXXS motif and 
      creates 14-3-3 binding sites, leading to cytoplasmic retention and functional 
      inactivation of TAZ. Ectopic expression of TAZ stimulates cell proliferation, 
      reduces cell contact inhibition, and promotes epithelial-mesenchymal transition 
      (EMT). Elimination of the Lats phosphorylation sites results in a constitutively 
      active TAZ, enhancing the activity of TAZ in promoting cell proliferation and 
      EMT. Our results elucidate a molecular mechanism for TAZ regulation and indicate 
      a potential function of TAZ as an important target of the Hippo pathway in 
      regulating cell proliferation tumorigenesis.
FAU - Lei, Qun-Ying
AU  - Lei QY
AD  - Department of Biological Chemistry, School of Medicine, Molecular and Cellular 
      Biology Laboratory, Institutes of Biomedical Sciences, Department of Biology, 
      School of Life Science, Fudan University, Shanghai 200032, China. 
      qlei@fudan.edu.cn
FAU - Zhang, Heng
AU  - Zhang H
FAU - Zhao, Bin
AU  - Zhao B
FAU - Zha, Zheng-Yu
AU  - Zha ZY
FAU - Bai, Feng
AU  - Bai F
FAU - Pei, Xin-Hai
AU  - Pei XH
FAU - Zhao, Shimin
AU  - Zhao S
FAU - Xiong, Yue
AU  - Xiong Y
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080128
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (14-3-3 Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (SAV1 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (YY1AP1 protein, human)
RN  - 0 (ex protein, Drosophila)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (TAFAZZIN protein, human)
RN  - EC 2.7.10.1 (MERTK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (c-Mer Tyrosine Kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (STK3 protein, human)
RN  - EC 2.7.11.1 (Serine-Threonine Kinase 3)
RN  - EC 2.7.8.- (SGMS1 protein, human)
RN  - EC 2.7.8.- (Transferases (Other Substituted Phosphate Groups))
SB  - IM
MH  - 14-3-3 Proteins/physiology
MH  - Acyltransferases
MH  - Amino Acid Motifs
MH  - Cell Cycle Proteins/genetics/physiology
MH  - Cell Division
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Transdifferentiation/physiology
MH  - Cell Transformation, Neoplastic
MH  - Conserved Sequence
MH  - Drosophila Proteins/genetics/physiology
MH  - Epithelial Cells/cytology
MH  - Humans
MH  - Membrane Proteins/genetics/physiology
MH  - Mesoderm/cytology
MH  - Nerve Tissue Proteins/genetics/physiology
MH  - Nuclear Proteins/physiology
MH  - Phosphorylation
MH  - Protein Processing, Post-Translational/*physiology
MH  - Protein Serine-Threonine Kinases/genetics/*physiology
MH  - Proteins/genetics/*physiology
MH  - Proto-Oncogene Proteins/genetics/physiology
MH  - Receptor Protein-Tyrosine Kinases/genetics/physiology
MH  - Recombinant Fusion Proteins/physiology
MH  - Serine-Threonine Kinase 3
MH  - Transcription Factors/genetics/*physiology
MH  - Transcription, Genetic
MH  - Transferases (Other Substituted Phosphate Groups)/genetics/physiology
MH  - c-Mer Tyrosine Kinase
PMC - PMC2268418
EDAT- 2008/01/30 09:00
MHDA- 2008/05/02 09:00
PMCR- 2008/08/01
CRDT- 2008/01/30 09:00
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/05/02 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
PHST- 2008/08/01 00:00 [pmc-release]
AID - MCB.01874-07 [pii]
AID - 1874-07 [pii]
AID - 10.1128/MCB.01874-07 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2008 Apr;28(7):2426-36. doi: 10.1128/MCB.01874-07. Epub 2008 Jan 
      28.