PMID- 18242222
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20220408
IS  - 1528-0012 (Electronic)
IS  - 0016-5085 (Linking)
VI  - 134
IP  - 2
DP  - 2008 Feb
TI  - Microbial influences in inflammatory bowel diseases.
PG  - 577-94
LID - 10.1053/j.gastro.2007.11.059 [doi]
AB  - The predominantly anaerobic microbiota of the distal ileum and colon contain an 
      extraordinarily complex variety of metabolically active bacteria and fungi that 
      intimately interact with the host's epithelial cells and mucosal immune system. 
      Crohn's disease, ulcerative colitis, and pouchitis are the result of continuous 
      microbial antigenic stimulation of pathogenic immune responses as a consequence 
      of host genetic defects in mucosal barrier function, innate bacterial killing, or 
      immunoregulation. Altered microbial composition and function in inflammatory 
      bowel diseases result in increased immune stimulation, epithelial dysfunction, or 
      enhanced mucosal permeability. Although traditional pathogens probably are not 
      responsible for these disorders, increased virulence of commensal bacterial 
      species, particularly Escherichia coli, enhance their mucosal attachment, 
      invasion, and intracellular persistence, thereby stimulating pathogenic immune 
      responses. Host genetic polymorphisms most likely interact with functional 
      bacterial changes to stimulate aggressive immune responses that lead to chronic 
      tissue injury. Identification of these host and microbial alterations in 
      individual patients should lead to selective targeted interventions that correct 
      underlying abnormalities and induce sustained and predictable therapeutic 
      responses.
FAU - Sartor, R Balfour
AU  - Sartor RB
AD  - Department of Medicine, Center for Gastrointestinal Biology and Disease, 
      University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 
      rbs@med.unc.edu
LA  - eng
GR  - P30 DK34987/DK/NIDDK NIH HHS/United States
GR  - P40 RR018603/RR/NCRR NIH HHS/United States
GR  - R01 DK40249/DK/NIDDK NIH HHS/United States
GR  - R01 DK53347/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
SB  - IM
MH  - Animals
MH  - Bacterial Infections/etiology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunity, Mucosal/immunology/*physiology
MH  - Inflammatory Bowel Diseases/complications/*microbiology/*physiopathology
MH  - Intestinal Mucosa/immunology/microbiology/physiopathology
MH  - Mice
MH  - Rats
RF  - 213
EDAT- 2008/02/05 09:00
MHDA- 2008/02/15 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/09/28 00:00 [received]
PHST- 2007/11/28 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0016-5085(07)02157-9 [pii]
AID - 10.1053/j.gastro.2007.11.059 [doi]
PST - ppublish
SO  - Gastroenterology. 2008 Feb;134(2):577-94. doi: 10.1053/j.gastro.2007.11.059.