PMID- 18256616
OWN - NLM
STAT- MEDLINE
DCOM- 20080421
LR  - 20220408
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 8
IP  - 3
DP  - 2008 Mar
TI  - DNA repair pathways as targets for cancer therapy.
PG  - 193-204
LID - 10.1038/nrc2342 [doi]
AB  - DNA repair pathways can enable tumour cells to survive DNA damage that is induced 
      by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair 
      pathways might prove efficacious when used in combination with DNA-damaging 
      chemotherapeutic drugs. In addition, alterations in DNA repair pathways that 
      arise during tumour development can make some cancer cells reliant on a reduced 
      set of DNA repair pathways for survival. There is evidence that drugs that 
      inhibit one of these pathways in such tumours could prove useful as single-agent 
      therapies, with the potential advantage that this approach could be selective for 
      tumour cells and have fewer side effects.
FAU - Helleday, Thomas
AU  - Helleday T
AD  - Radiation Oncology & Biology, University of Oxford, Old Road Campus Research 
      Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK. 
      thomas.helleday@rob.ox.ac.uk
FAU - Petermann, Eva
AU  - Petermann E
FAU - Lundin, Cecilia
AU  - Lundin C
FAU - Hodgson, Ben
AU  - Hodgson B
FAU - Sharma, Ricky A
AU  - Sharma RA
LA  - eng
GR  - 8971/CRUK_/Cancer Research UK/United Kingdom
GR  - G0700730/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Antineoplastic Agents)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Cell Survival
MH  - DNA Damage
MH  - *DNA Repair
MH  - DNA Repair Enzymes
MH  - Humans
MH  - Medical Oncology/methods/trends
MH  - Models, Biological
MH  - Neoplasms/*therapy
MH  - Treatment Outcome
RF  - 135
EDAT- 2008/02/08 09:00
MHDA- 2008/04/22 09:00
CRDT- 2008/02/08 09:00
PHST- 2008/02/08 09:00 [pubmed]
PHST- 2008/04/22 09:00 [medline]
PHST- 2008/02/08 09:00 [entrez]
AID - nrc2342 [pii]
AID - 10.1038/nrc2342 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2008 Mar;8(3):193-204. doi: 10.1038/nrc2342.