PMID- 18258486
OWN - NLM
STAT- MEDLINE
DCOM- 20080416
LR  - 20211203
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Linking)
VI  - 14
IP  - 3
DP  - 2008 Mar
TI  - The TEAD/TEF family protein Scalloped mediates transcriptional output of the 
      Hippo growth-regulatory pathway.
PG  - 388-98
LID - 10.1016/j.devcel.2008.01.007 [doi]
AB  - The Hippo (Hpo) kinase cascade restricts tissue growth by inactivating the 
      transcriptional coactivator Yorkie (Yki), which regulates the expression of 
      target genes such as the cell death inhibitor diap1 by unknown mechanisms. Here 
      we identify the TEAD/TEF family protein Scalloped (Sd) as a DNA-binding 
      transcription factor that partners with Yki to mediate the transcriptional output 
      of the Hpo growth-regulatory pathway. The diap1 (th) locus harbors a minimal 
      Sd-binding Hpo Responsive Element (HRE) that mediates transcriptional regulation 
      by the Hpo pathway. Sd binds directly to Yki, and a Yki missense mutation that 
      abrogates Sd-Yki binding also inactivates Yki function in vivo. We further 
      demonstrate that sd is required for yki-induced tissue overgrowth and target gene 
      expression, and that sd activity is conserved in its mammalian homolog. Our 
      results uncover a heretofore missing link in the Hpo signaling pathway and 
      provide a glimpse of the molecular events on a Hpo-responsive enhancer element.
FAU - Wu, Shian
AU  - Wu S
AD  - Department of Molecular Biology and Genetics, Johns Hopkins University School of 
      Medicine, Baltimore, MD 21205, USA.
FAU - Liu, Yi
AU  - Liu Y
FAU - Zheng, Yonggang
AU  - Zheng Y
FAU - Dong, Jixin
AU  - Dong J
FAU - Pan, Duojia
AU  - Pan D
LA  - eng
GR  - EY015708/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080207
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (DIAP1 protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - 0 (sd protein, Drosophila)
RN  - 0 (vg protein, Drosophila)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
CIN - Dev Cell. 2008 Mar;14(3):315-6. PMID: 18331708
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - DNA/genetics/metabolism
MH  - Drosophila/genetics/growth & development/*physiology
MH  - Drosophila Proteins/genetics/*physiology
MH  - Epistasis, Genetic
MH  - Gene Dosage
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - Inhibitor of Apoptosis Proteins/genetics
MH  - Intracellular Signaling Peptides and Proteins/genetics/*physiology
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Nuclear Proteins/genetics/physiology
MH  - Organ Size/physiology
MH  - Protein Serine-Threonine Kinases/genetics/*physiology
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Trans-Activators/genetics/physiology
MH  - Transcription Factors/genetics/*physiology
MH  - Transcription, Genetic
MH  - Wings, Animal/growth & development
MH  - YAP-Signaling Proteins
EDAT- 2008/02/09 09:00
MHDA- 2008/04/17 09:00
CRDT- 2008/02/09 09:00
PHST- 2007/10/22 00:00 [received]
PHST- 2008/01/17 00:00 [revised]
PHST- 2008/01/18 00:00 [accepted]
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2008/04/17 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
AID - S1534-5807(08)00035-X [pii]
AID - 10.1016/j.devcel.2008.01.007 [doi]
PST - ppublish
SO  - Dev Cell. 2008 Mar;14(3):388-98. doi: 10.1016/j.devcel.2008.01.007. Epub 2008 Feb 
      7.