PMID- 18259690
OWN - NLM
STAT- MEDLINE
DCOM- 20080709
LR  - 20220410
IS  - 1420-682X (Print)
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Linking)
VI  - 65
IP  - 10
DP  - 2008 May
TI  - The epidermal growth factor receptor family: biology driving targeted 
      therapeutics.
PG  - 1566-84
LID - 10.1007/s00018-008-7440-8 [doi]
AB  - The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays 
      essential roles in regulating cell proliferation, survival, differentiation and 
      migration. The ErbB receptors carry out both redundant and restricted functions 
      in mammalian development and in the maintenance of tissues in the adult mammal. 
      Loss of regulation of the ErbB receptors underlies many human diseases, most 
      notably cancer. Our understanding of the function and complex regulation of these 
      receptors has fueled the development of targeted therapeutic agents for human 
      malignancies in the last 15 years. Here we review the biology of ErbB receptors, 
      including their structure, signaling, regulation, and roles in development and 
      disease, then briefly touch on their increasing roles as targets for cancer 
      therapy.
FAU - Wieduwilt, M J
AU  - Wieduwilt MJ
AD  - Department of Medicine, Comprehensive Cancer Center, University of California-San 
      Francisco, San Francisco, CA 94143-0875, USA.
FAU - Moasser, M M
AU  - Moasser MM
LA  - eng
GR  - R01 CA122216/CA/NCI NIH HHS/United States
GR  - R01 CA122216-02/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Animals
MH  - Cell Nucleus/metabolism
MH  - Disease/etiology
MH  - *Drug Delivery Systems
MH  - Drug Resistance, Neoplasm/genetics
MH  - Embryonic Development/genetics
MH  - ErbB Receptors/genetics/metabolism/*physiology
MH  - Genes, erbB/physiology
MH  - Humans
MH  - Models, Biological
MH  - Multigene Family
MH  - Neoplasms/*drug therapy/genetics
MH  - Receptor Cross-Talk/physiology
MH  - Signal Transduction/physiology
PMC - PMC3060045
MID - NIHMS279050
EDAT- 2008/02/09 09:00
MHDA- 2008/07/10 09:00
PMCR- 2011/03/17
CRDT- 2008/02/09 09:00
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2008/07/10 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
PHST- 2011/03/17 00:00 [pmc-release]
AID - 10.1007/s00018-008-7440-8 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2008 May;65(10):1566-84. doi: 10.1007/s00018-008-7440-8.