PMID- 18295580
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20230425
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 132
IP  - 4
DP  - 2008 Feb 22
TI  - Hematopoiesis: an evolving paradigm for stem cell biology.
PG  - 631-44
LID - 10.1016/j.cell.2008.01.025 [doi]
AB  - Establishment and maintenance of the blood system relies on self-renewing 
      hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone 
      marrow niche of adult mammals. This Review describes the developmental origins of 
      HSCs and the molecular mechanisms that regulate lineage-specific differentiation. 
      Studies of hematopoiesis provide critical insights of general relevance to other 
      areas of stem cell biology including the role of cellular interactions in 
      development and tissue homeostasis, lineage programming and reprogramming by 
      transcription factors, and stage- and age-specific differences in cellular 
      phenotypes.
FAU - Orkin, Stuart H
AU  - Orkin SH
AD  - Division of Hematology/Oncology, Children's Hospital Boston and the Dana Farber 
      Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 
      02115, USA. stuart_orkin@dfci.harvard.edu
FAU - Zon, Leonard I
AU  - Zon LI
LA  - eng
GR  - R01 HL075735-06/HL/NHLBI NIH HHS/United States
GR  - R01 HL075735/HL/NHLBI NIH HHS/United States
GR  - R01 HL032259/HL/NHLBI NIH HHS/United States
GR  - P01 HL032262/HL/NHLBI NIH HHS/United States
GR  - R01 HL032259-27/HL/NHLBI NIH HHS/United States
GR  - P30 DK049216-15/DK/NIDDK NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - P30 DK049216/DK/NIDDK NIH HHS/United States
GR  - P01 HL032262-27/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cell Lineage
MH  - Cell Movement
MH  - *Hematopoiesis
MH  - Hematopoietic Stem Cells/cytology
MH  - Humans
MH  - Transcription Factors/metabolism
PMC - PMC2628169
MID - NIHMS74857
OID - NLM: HHMIMS74857
EDAT- 2008/02/26 09:00
MHDA- 2008/03/05 09:00
PMCR- 2009/01/16
CRDT- 2008/02/26 09:00
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
PHST- 2009/01/16 00:00 [pmc-release]
AID - S0092-8674(08)00125-6 [pii]
AID - 10.1016/j.cell.2008.01.025 [doi]
PST - ppublish
SO  - Cell. 2008 Feb 22;132(4):631-44. doi: 10.1016/j.cell.2008.01.025.