PMID- 18308616
OWN - NLM
STAT- MEDLINE
DCOM- 20080707
LR  - 20220410
IS  - 1359-6101 (Print)
IS  - 1359-6101 (Linking)
VI  - 19
IP  - 2
DP  - 2008 Apr
TI  - IGF2: epigenetic regulation and role in development and disease.
PG  - 111-20
LID - 10.1016/j.cytogfr.2008.01.005 [doi]
AB  - Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of 
      all growth factors characterized to date. Its gene is imprinted--only one allele 
      is active, depending on parental origin--and this pattern of expression is 
      maintained epigenetically in almost all tissues. IGF2 activity is further 
      controlled through differential expression of receptors and IGF-binding proteins 
      (IGFBPs) that determine protein availability. This complex and multifaceted 
      regulation emphasizes the importance of accurate IGF2 expression and activity. 
      This review will examine the regulation of the IGF2 gene and what it has revealed 
      about the phenomenon of imprinting, which is frequently disrupted in cancer. IGF2 
      protein function will be discussed, along with diseases that involve IGF2 
      overexpression. Roles for IGF2 in sonic hedgehog (Shh) signaling and angiogenesis 
      will also be explored.
FAU - Chao, Wendy
AU  - Chao W
AD  - Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, United 
      States. wendychao@post.harvard.edu
FAU - D'Amore, Patricia A
AU  - D'Amore PA
LA  - eng
GR  - R01 EY005318/EY/NEI NIH HHS/United States
GR  - R01 EY005318-24/EY/NEI NIH HHS/United States
GR  - R01 EY015435/EY/NEI NIH HHS/United States
GR  - R01 EY015435-04/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20080304
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Binding Sites
MH  - Cell Differentiation
MH  - *Epigenesis, Genetic
MH  - *Gene Expression Regulation, Developmental
MH  - Genomic Imprinting
MH  - Hedgehog Proteins/metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor II/*genetics/metabolism/*physiology
MH  - Models, Biological
MH  - Neovascularization, Pathologic
MH  - Neovascularization, Physiologic
MH  - Signal Transduction
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC2314671
MID - NIHMS45387
EDAT- 2008/03/01 09:00
MHDA- 2008/07/08 09:00
PMCR- 2009/04/01
CRDT- 2008/03/01 09:00
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2008/07/08 09:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
PHST- 2009/04/01 00:00 [pmc-release]
AID - S1359-6101(08)00007-5 [pii]
AID - 10.1016/j.cytogfr.2008.01.005 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2008 Apr;19(2):111-20. doi: 
      10.1016/j.cytogfr.2008.01.005. Epub 2008 Mar 4.