PMID- 18328423
OWN - NLM
STAT- MEDLINE
DCOM- 20080403
LR  - 20221109
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 13
IP  - 3
DP  - 2008 Mar
TI  - The emerging role of the hippo pathway in cell contact inhibition, organ size 
      control, and cancer development in mammals.
PG  - 188-92
LID - 10.1016/j.ccr.2008.02.011 [doi]
AB  - The Hippo pathway defined originally in Drosophila melanogaster is conserved in 
      mammals. The fly core components Hippo, Sav, Wts, and Mats are conserved in 
      mammals as Mst1/2, WW45, LATS1/2, and Mob1. The pathway impinges on 
      transcriptional coactivator Yorkie in fly and YAP in mammals to coordinate cell 
      proliferation and apoptosis. Several recent publications establish that the 
      pathway is one major conserved mechanism governing cell contact inhibition, organ 
      size control, and cancer development. This advance opens new vistas in exploring 
      fundamental mechanisms in cell and developmental biology and offers potential 
      targets to interfere with cancer development.
FAU - Zeng, Qi
AU  - Zeng Q
AD  - Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell 
      Biology, A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, 
      Singapore 138673, Singapore.
FAU - Hong, Wanjin
AU  - Hong W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YY1AP1 protein, human)
RN  - 0 (Yki protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Cell Cycle Proteins
MH  - *Cell Proliferation
MH  - Cell Transformation, Neoplastic/*metabolism/pathology
MH  - Drosophila Proteins/metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Nuclear Proteins/metabolism
MH  - Organ Size
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - *Signal Transduction
MH  - Trans-Activators/metabolism
MH  - Transcription Factors/metabolism
MH  - YAP-Signaling Proteins
RF  - 42
EDAT- 2008/03/11 09:00
MHDA- 2008/04/04 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/04/04 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S1535-6108(08)00047-0 [pii]
AID - 10.1016/j.ccr.2008.02.011 [doi]
PST - ppublish
SO  - Cancer Cell. 2008 Mar;13(3):188-92. doi: 10.1016/j.ccr.2008.02.011.