PMID- 18337078
OWN - NLM
STAT- MEDLINE
DCOM- 20080707
LR  - 20220408
IS  - 0955-0674 (Print)
IS  - 0955-0674 (Linking)
VI  - 20
IP  - 2
DP  - 2008 Apr
TI  - Assembly and biological role of podosomes and invadopodia.
PG  - 235-41
LID - 10.1016/j.ceb.2008.01.005 [doi]
AB  - Regulated tissue invasion via motile and lytic events is critical for 
      physiological processes such as immune system function and inflammatory 
      responses, wound healing, and organ development, but pathological subversion of 
      this process drives tumour cell invasion and metastasis. Cell migration and 
      invasion require the integration of several processes that include: first, the 
      local modulation of cytoskeleton structure and contractile forces; second, the 
      turnover of substrate adhesions and their associated microfilaments; and third, 
      the generation of specialised, transient domains that mediate the 
      protease-dependent focal degradation of the extracellular matrix. Recent work has 
      re-discovered prominent actin-based cellular structures, termed invadopodia and 
      podosomes, as unique structural and functional modules through which major 
      invasive mechanisms are regulated. The stage is now set to unravel their roles in 
      the physiology and pathology of tissue plasticity and repair.
FAU - Gimona, Mario
AU  - Gimona M
AD  - Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of 
      Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro Chieti, 
      Italy. gimona@negrisud.it
FAU - Buccione, Roberto
AU  - Buccione R
FAU - Courtneidge, Sara A
AU  - Courtneidge SA
FAU - Linder, Stefan
AU  - Linder S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080311
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (Actins)
RN  - 0 (Molecular Motor Proteins)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Cell Adhesion
MH  - Humans
MH  - Microtubules/metabolism
MH  - Molecular Motor Proteins/metabolism
MH  - Pseudopodia/*metabolism
RF  - 51
EDAT- 2008/03/14 09:00
MHDA- 2008/07/08 09:00
CRDT- 2008/03/14 09:00
PHST- 2007/12/23 00:00 [received]
PHST- 2008/01/26 00:00 [accepted]
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/07/08 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - S0955-0674(08)00014-8 [pii]
AID - 10.1016/j.ceb.2008.01.005 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2008 Apr;20(2):235-41. doi: 10.1016/j.ceb.2008.01.005. Epub 
      2008 Mar 11.