PMID- 18436437
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20211020
IS  - 0955-0674 (Print)
IS  - 0955-0674 (Linking)
VI  - 20
IP  - 3
DP  - 2008 Jun
TI  - The RNA polymerase II core promoter - the gateway to transcription.
PG  - 253-9
LID - 10.1016/j.ceb.2008.03.003 [doi]
AB  - The RNA polymerase II core promoter is generally defined to be the sequence that 
      directs the initiation of transcription. This simple definition belies a diverse 
      and complex transcriptional module. There are two major types of core promoters - 
      focused and dispersed. Focused promoters contain either a single transcription 
      start site or a distinct cluster of start sites over several nucleotides, whereas 
      dispersed promoters contain several start sites over 50-100 nucleotides and are 
      typically found in CpG islands in vertebrates. Focused promoters are more ancient 
      and widespread throughout nature than dispersed promoters; however, in 
      vertebrates, dispersed promoters are more common than focused promoters. In 
      addition, core promoters may contain many different sequence motifs, such as the 
      TATA box, BRE, Inr, MTE, DPE, DCE, and XCPE1, that specify different mechanisms 
      of transcription and responses to enhancers. Thus, the core promoter is a 
      sophisticated gateway to transcription that determines which signals will lead to 
      transcription initiation.
FAU - Juven-Gershon, Tamar
AU  - Juven-Gershon T
AD  - Section of Molecular Biology, University of California, San Diego, 9500 Gilman 
      Drive, La Jolla, CA 92093-0347, USA.
FAU - Hsu, Jer-Yuan
AU  - Hsu JY
FAU - Theisen, Joshua Wm
AU  - Theisen JW
FAU - Kadonaga, James T
AU  - Kadonaga JT
LA  - eng
GR  - GM041249/GM/NIGMS NIH HHS/United States
GR  - R01 GM041249/GM/NIGMS NIH HHS/United States
GR  - R01 GM041249-19S1/GM/NIGMS NIH HHS/United States
GR  - R01 GM041249-19/GM/NIGMS NIH HHS/United States
GR  - R01 GM041249-20/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080422
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.7.6 (DNA-Directed RNA Polymerases)
SB  - IM
MH  - Animals
MH  - Base Sequence/genetics
MH  - DNA-Directed RNA Polymerases/*genetics
MH  - Evolution, Molecular
MH  - Humans
MH  - Promoter Regions, Genetic/*genetics
MH  - RNA, Messenger/*biosynthesis/*genetics
MH  - TATA Box/genetics
MH  - Transcription Initiation Site/physiology
MH  - Transcription, Genetic/*genetics
MH  - Transcriptional Activation/genetics
PMC - PMC2586601
MID - NIHMS55640
EDAT- 2008/04/26 09:00
MHDA- 2008/09/20 09:00
PMCR- 2008/11/24
CRDT- 2008/04/26 09:00
PHST- 2008/01/14 00:00 [received]
PHST- 2008/03/11 00:00 [accepted]
PHST- 2008/04/26 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/04/26 09:00 [entrez]
PHST- 2008/11/24 00:00 [pmc-release]
AID - S0955-0674(08)00035-5 [pii]
AID - 10.1016/j.ceb.2008.03.003 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2008 Jun;20(3):253-9. doi: 10.1016/j.ceb.2008.03.003. Epub 
      2008 Apr 22.