PMID- 18698017
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20240109
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 14
IP  - 16
DP  - 2008 Aug 15
TI  - Survivin: key regulator of mitosis and apoptosis and novel target for cancer 
      therapeutics.
PG  - 5000-5
LID - 10.1158/1078-0432.CCR-08-0746 [doi]
AB  - Survivin, a member of the family of inhibitor of apoptosis proteins, functions as 
      a key regulator of mitosis and programmed cell death. Initially, survivin was 
      described as an inhibitor of caspase-9. However, over the last years, research 
      studies have shown that the role of survivin in cancer pathogenesis is not 
      limited to apoptosis inhibition but also involves the regulation of the mitotic 
      spindle checkpoint and the promotion of angiogenesis and chemoresistance. 
      Survivin gene expression is transcriptionally repressed by wild-type p53 and can 
      be deregulated in cancer by several mechanisms, including gene amplification, 
      hypomethylation, increased promoter activity, and loss of p53 function. This 
      article reviews the multiple functions of survivin in the regulation of 
      apoptosis, the promotion of tumorigenesis, and the development of survivin 
      inhibitors as a novel anticancer therapeutic strategy.
FAU - Mita, Alain C
AU  - Mita AC
AD  - Institute for Drug Development, Cancer Therapy and Research Center at the 
      University of Texas Health Science Center, 7979 Wurzbach Road, San Antonio, TX 
      78229, USA. amita@idd.org
FAU - Mita, Monica M
AU  - Mita MM
FAU - Nawrocki, Steffan T
AU  - Nawrocki ST
FAU - Giles, Francis J
AU  - Giles FJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (Antineoplastic Agents)
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/*physiology
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Microtubule-Associated Proteins/*physiology
MH  - Mitosis/*physiology
MH  - Neoplasm Proteins/*physiology
MH  - Neoplasms/drug therapy/*metabolism
MH  - Signal Transduction/*physiology
MH  - Survivin
RF  - 85
EDAT- 2008/08/14 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/08/14 09:00
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
AID - 14/16/5000 [pii]
AID - 10.1158/1078-0432.CCR-08-0746 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2008 Aug 15;14(16):5000-5. doi: 10.1158/1078-0432.CCR-08-0746.