PMID- 18698034
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20220409
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 14
IP  - 16
DP  - 2008 Aug 15
TI  - Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas.
PG  - 5166-72
LID - 10.1158/1078-0432.CCR-08-0320 [doi]
AB  - PURPOSE: The incidence of regulatory T cells (Treg) in intrinsic central nervous 
      system malignancies is unknown. Immunotherapeutic approaches that inhibit the 
      Treg population may be limited to a subset of patients with gliomas. Our 
      hypothesis is that only the most malignant gliomas have a prominent 
      glioma-infiltrating Treg population that contributes to the immunosuppressive 
      biology and that the presence of Tregs is a negative prognostic variable. 
      EXPERIMENTAL DESIGN: We measured the incidence of Tregs in 135 glial tumors 
      (including all pathologic types) in a glioma microarray using immunohistochemical 
      analysis. Results were categorized according to the total number of Tregs within 
      the tumors. Correlation of the presence of Tregs with prognosis was evaluated 
      using univariate and multivariate analyses. RESULTS: Tregs were not present in 
      normal brain tissue and were very rarely found in low-grade gliomas and 
      oligodendrogliomas. We observed significant differences in the prevalence of 
      Tregs between astrocytic and oligodendroglial tumors, between tumors of different 
      grades, and between different pathologic types of tumors. We identified Tregs 
      most frequently in glioblastoma multiforme (GBM) but very rarely in low-grade 
      astrocytomas. The presence of Tregs within GBMs did not alter the median survival 
      in patients from whom the tumors were obtained. CONCLUSIONS: Treg infiltration 
      differed significantly in the tumors according to lineage, pathology, and grade. 
      Tregs seemed to have the highest predilection for tumors of the astrocytic 
      lineage and specifically in the high-grade gliomas, such as GBM. In both 
      univariate and multivariate analysis, the presence of Tregs in GBMs seemed to be 
      prognostically neutral.
FAU - Heimberger, Amy B
AU  - Heimberger AB
AD  - Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 
      Houston, Texas 77030, USA. aheimber@mdanderson.org
FAU - Abou-Ghazal, Mohamed
AU  - Abou-Ghazal M
FAU - Reina-Ortiz, Chantal
AU  - Reina-Ortiz C
FAU - Yang, David S
AU  - Yang DS
FAU - Sun, Wei
AU  - Sun W
FAU - Qiao, Wei
AU  - Qiao W
FAU - Hiraoka, Nobuyoshi
AU  - Hiraoka N
FAU - Fuller, Gregory N
AU  - Fuller GN
LA  - eng
GR  - R01 CA120813-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*immunology
MH  - Brain Neoplasms/*immunology/mortality/pathology
MH  - Cell Lineage
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Flow Cytometry
MH  - Forkhead Transcription Factors/*metabolism
MH  - Glioma/*immunology/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Lymphocytes, Tumor-Infiltrating/*immunology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - T-Lymphocyte Subsets/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Tissue Array Analysis
EDAT- 2008/08/14 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/08/14 09:00
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
AID - 14/16/5166 [pii]
AID - 10.1158/1078-0432.CCR-08-0320 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2008 Aug 15;14(16):5166-72. doi: 10.1158/1078-0432.CCR-08-0320.