PMID- 18834311
OWN - NLM
STAT- MEDLINE
DCOM- 20090427
LR  - 20220309
IS  - 0362-1642 (Print)
IS  - 0362-1642 (Linking)
VI  - 49
DP  - 2009
TI  - The role of Gbetagamma subunits in the organization, assembly, and function of 
      GPCR signaling complexes.
PG  - 31-56
LID - 10.1146/annurev-pharmtox-061008-103038 [doi]
AB  - The role of Gbetagamma subunits in cellular signaling has become well established 
      in the past 20 years. Not only do they regulate effectors once thought to be the 
      sole targets of Galpha subunits, but it has become clear that they also have a 
      unique set of binding partners and regulate signaling pathways that are not 
      always localized to the plasma membrane. However, this may be only the beginning 
      of the story. Gbetagamma subunits interact with G protein-coupled receptors, 
      Galpha subunits, and several different effector molecules during assembly and 
      trafficking of receptor-based signaling complexes and not simply in response to 
      ligand stimulation at sites of receptor cellular activity. Gbetagamma assembly 
      itself seems to be tightly regulated via the action of molecular chaperones and 
      in turn may serve a similar role in the assembly of specific signaling complexes. 
      We propose that specific Gbetagamma subunits have a broader role in controlling 
      the architecture, assembly, and activity of cellular signaling pathways.
FAU - Dupre, Denis J
AU  - Dupre DJ
AD  - Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. 
      denis.dupre@dal.ca
FAU - Robitaille, Melanie
AU  - Robitaille M
FAU - Rebois, R Victor
AU  - Rebois RV
FAU - Hebert, Terence E
AU  - Hebert TE
LA  - eng
GR  - Z01 DC000067-02/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (GTP-Binding Protein beta Subunits)
RN  - 0 (GTP-Binding Protein gamma Subunits)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - GTP-Binding Protein beta Subunits/chemistry/*metabolism
MH  - GTP-Binding Protein gamma Subunits/chemistry/*metabolism
MH  - Humans
MH  - Models, Theoretical
MH  - Receptors, G-Protein-Coupled/chemistry/*metabolism
MH  - *Signal Transduction
PMC - PMC2659589
MID - NIHMS71026
EDAT- 2008/10/07 09:00
MHDA- 2009/04/28 09:00
PMCR- 2009/03/23
CRDT- 2008/10/07 09:00
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/04/28 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
PHST- 2009/03/23 00:00 [pmc-release]
AID - 10.1146/annurev-pharmtox-061008-103038 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2009;49:31-56. doi: 
      10.1146/annurev-pharmtox-061008-103038.