PMID- 1902986
OWN - NLM
STAT- MEDLINE
DCOM- 19910611
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 252
IP  - 5007
DP  - 1991 May 10
TI  - Diversity of G proteins in signal transduction.
PG  - 802-8
AB  - The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as 
      switches that regulate information processing circuits connecting cell surface 
      receptors to a variety of effectors. The G proteins are present in all eukaryotic 
      cells, and they control metabolic, humoral, neural, and developmental functions. 
      More than a hundred different kinds of receptors and many different effectors 
      have been described. The G proteins that coordinate receptor-effector activity 
      are derived from a large gene family. At present, the family is known to contain 
      at least sixteen different genes that encode the alpha subunit of the 
      heterotrimer, four that encode beta subunits, and multiple genes encoding gamma 
      subunits. Specific transient interactions between these components generate the 
      pathways that modulate cellular responses to complex chemical signals.
FAU - Simon, M I
AU  - Simon MI
AD  - Division of Biology, California Institute of Technology, Pasadena 91125.
FAU - Strathmann, M P
AU  - Strathmann MP
FAU - Gautam, N
AU  - Gautam N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Chromosome Mapping
MH  - GTP-Binding Proteins/*chemistry
MH  - Gene Expression Regulation
MH  - Molecular Sequence Data
MH  - Signal Transduction/*physiology
RF  - 86
EDAT- 1991/05/10 00:00
MHDA- 1991/05/10 00:01
CRDT- 1991/05/10 00:00
PHST- 1991/05/10 00:00 [pubmed]
PHST- 1991/05/10 00:01 [medline]
PHST- 1991/05/10 00:00 [entrez]
AID - 10.1126/science.1902986 [doi]
PST - ppublish
SO  - Science. 1991 May 10;252(5007):802-8. doi: 10.1126/science.1902986.